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Introduction
Historical perspective
Clinical description
Comorbid conditions
Classification
Epidemiology
Etiopathogenesis (psychodynamic theories, biological models, genetics)
Etiopathogenesis (psychodynamic theories, biological models, genetics)
Assessment (psychometric, neuropsychological, scales)
Therapy
Biological therapies (separate for mania, depression and maintenance)
Randomized Controlled Trials (RCTs)
Meta-analysis
Open trials
Review and opinion papers
Pharmacoepidemiologic data
Psychosocial therapies
Treatment guidelines
Cautions for pharmaceutical treatment in bipolar patients
Switching to the opposite pole
Psychogeriatric issues
Suicidality
Gender issues
Pediatric bipolar disorder
Conclusion.

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