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000724746 0247_ $$a10.1007/978-3-658-08344-1$$2doi
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000724746 1001_ $$aOn, Thomas,$$eauthor.
000724746 24510 $$aOptimized response-adaptive clinical trials$$h[electronic resource] :$$bsequential treatment allocation based on Markov decision problems /$$cThomas Ondra.
000724746 264_1 $$aWiesbaden :$$bSpringer Spektrum,$$c2015.
000724746 300__ $$a1 online resource (xv, 102 pages) :$$billustrations.
000724746 336__ $$atext$$btxt$$2rdacontent
000724746 337__ $$acomputer$$bc$$2rdamedia
000724746 338__ $$aonline resource$$bcr$$2rdacarrier
000724746 347__ $$atext file$$bPDF$$2rda
000724746 4901_ $$aBestMasters
000724746 504__ $$aIncludes bibliographical references.
000724746 5050_ $$aIntroduction to Markov Decision Problems and Examples -- Finite and Infinite Horizon Markov Decision Problems -- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration -- Designing Response Adaptive Clinical Trials with Markov Decision Problems.
000724746 506__ $$aAccess limited to authorized users.
000724746 520__ $$aTwo-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences. Contents Introduction to Markov Decision Problems and Examples Finite and Infinite Horizon Markov Decision Problems Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration Designing Response Adaptive Clinical Trials with Markov Decision Problems Target Groups Researchers and students in the fields of mathematics and statistics Professionals in the pharmaceutical industry The Author Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
000724746 546__ $$aAbstract in German and English
000724746 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed Feb. 26, 2015).
000724746 650_0 $$aClinical trials$$xStatistical methods.
000724746 650_0 $$aMarkov processes.
000724746 77608 $$iPrint version:$$z9783658083434
000724746 830_0 $$aBestMasters.
000724746 852__ $$bebk
000724746 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-658-08344-1$$zOnline Access$$91397441.1
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