Optimized response-adaptive clinical trials [electronic resource] : sequential treatment allocation based on Markov decision problems / Thomas Ondra.
2015
R853.S7 O5 2015eb
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Title
Optimized response-adaptive clinical trials [electronic resource] : sequential treatment allocation based on Markov decision problems / Thomas Ondra.
Author
ISBN
9783658083441 electronic book
3658083441 electronic book
9783658083434
3658083441 electronic book
9783658083434
Published
Wiesbaden : Springer Spektrum, 2015.
Language
English
Language Note
Abstract in German and English
Description
1 online resource (xv, 102 pages) : illustrations.
Item Number
10.1007/978-3-658-08344-1 doi
Call Number
R853.S7 O5 2015eb
Dewey Decimal Classification
610.72/4
510
510
Summary
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences. Contents Introduction to Markov Decision Problems and Examples Finite and Infinite Horizon Markov Decision Problems Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration Designing Response Adaptive Clinical Trials with Markov Decision Problems Target Groups Researchers and students in the fields of mathematics and statistics Professionals in the pharmaceutical industry The Author Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
Bibliography, etc. Note
Includes bibliographical references.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed Feb. 26, 2015).
Series
BestMasters.
Available in Other Form
Print version: 9783658083434
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Table of Contents
Introduction to Markov Decision Problems and Examples
Finite and Infinite Horizon Markov Decision Problems
Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
Designing Response Adaptive Clinical Trials with Markov Decision Problems.
Finite and Infinite Horizon Markov Decision Problems
Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
Designing Response Adaptive Clinical Trials with Markov Decision Problems.