Behçet's disease [electronic resource] : from genetics to therapies / Yoshiaki Ishigatsubo, editor.

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Behçet's disease [electronic resource] : from genetics to therapies / Yoshiaki Ishigatsubo, editor.

9784431544876 electronic book
4431544879 electronic book
9784431544869

Tokyo : Springer, 2015.

English

1 online resource (ix, 176 pages) : illustrations (some color)

10.1007/978-4-431-54487-6 doi

RC122.B4

616.9

This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.

Includes index.

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Online resource; title from PDF title page (SpringerLink, viewed February 19, 2015).

Print version: 9784431544869

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