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000724824 019__ $$a908083105
000724824 020__ $$a9781493918188$$qelectronic book
000724824 020__ $$a1493918184$$qelectronic book
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000724824 24500 $$aTreatment of chronic pain by medical approaches$$h[electronic resource] :$$bthe American Academy of Pain Medicine textbook on patient management /$$cTimothy R. Deer, editor-in-chief, Michael S. Leong, associate editor-in-chief, Vitaly Gordin, associate editor.
000724824 264_1 $$aNew York, NY :$$bSpringer,$$c[2014].
000724824 264_4 $$c©2015
000724824 300__ $$a1 online resource (xix, 219 pages) :$$billustrations (some color)
000724824 336__ $$atext$$btxt$$2rdacontent
000724824 337__ $$acomputer$$bc$$2rdamedia
000724824 338__ $$aonline resource$$bcr$$2rdacarrier
000724824 500__ $$aIncludes index.
000724824 5050_ $$aForeword to Comprehensive Treatmentof Chronic Pain by Medical, Interventional,and Integrative Approaches; Foreword to Comprehensive Treatmentof Chronic Pain by Medical, Interventional,and Integrative Approaches; Preface to Treatment of Chronic Pain by Medical Approaches; Preface to Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches; Contents; Contributors; 1: A Survey of Systems Involved in Nociceptive Processing; Key Points; Background; Overview of the Psychophysics of Nociception; Acute Stimulation; Tissue Injury; Nerve Injury
000724824 5058_ $$aEncoding of Acute NociceptionTransduction Channels and Afferent Terminal Activation; Chemical Sensitivity of Temperature Channels; Action Potential Generation; Encoding Properties of Primary Afferents; Afferent Synaptic Transmission; Calcium Channels and Afferent Transmitter Release; Spinal Afferent Terminal Transmitters; Laminar Organization of Spinal Dorsal Horn; Primary Afferent Projections; Dorsal Horn Neurons; Dorsal Horn Projections; Supraspinal Organization; Encoding of Nociception After Tissue Injury; Peripheral Changes in Afferent Transmission Resulting from Tissue
000724824 5058_ $$aOrigin of Ongoing Activity and Enhanced Terminal Responsiveness After Tissue Injury Spinal Changes in Afferent Transmission Resulting from Tissue Injury; Central (Spinal) Facilitation; Enhanced Response of WDR Neuron; Pharmacology of Central Facilitation; Primary Afferents; Postsynaptic to the Primary Afferents; Local Interneuronal Networks; Bulbospinal Systems; Nonneuronal Cells; Evolution of a Chronic Pain State After Acute Injury; Summary; Encoding of Nociception After Nerve Injury; Events Initiated by Nerve Injury; Origins of Spontaneous Pain State
000724824 5058_ $$aSite of Origin of Spontaneous Afferent Traffic Mechanisms of Ongoing Activity; Increased Sodium Channel Expression; Decreased K Channel Expression; Inflammatory Products; Origins of Evoke Hyperpathia; Dorsal Root Ganglion Cell Cross Talk; Afferent Sprouting; Loss of Intrinsic GABAergic/Glycinergic Inhibitory Control; Nonneuronal Cells and Nerve Injury; Sympathetic Dependency; Generalization to Many Nerve Injury Pain States; Conclusions; References; 2: Pharmacogenomics of Pain Management; Key Points; Introduction; Background; Functional Genomics of Pain
000724824 5058_ $$aPharmacogenomics of Pain Therapy and Its Usefulness in Clinical Practice Genetic Variations in the Prodrug Activation; Genetic Variations in the Elimination of Analgesic Drugs; Genetic Variations in the Transmembrane Transport of Analgesics; Pharmacodynamics of Pain Therapy; Opioid Receptors; Catechol-O-Methyltransferase (COMT); Melanocortin 1 Receptor (MC1R); Cyclooxygenases (COX); Future Direction of Pharmacogenomics in Pain Treatment; Summary; References; 3: Nonsteroidal Anti-inflammatory Drugs; Key Points; Introduction; Mechanism of Action; Pharmacokinetics; Absorption.
000724824 506__ $$aAccess limited to authorized users.
000724824 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed December 23, 2014).
000724824 650_0 $$aChronic pain$$xTreatment.
000724824 7001_ $$aDeer, Timothy R.,$$eeditor.
000724824 7001_ $$aLeong, Michael S.,$$eeditor.
000724824 7001_ $$aGordin, Vitaly,$$eeditor.
000724824 77608 $$iPrint version:$$aDeer, Timothy R.$$tTreatment of Chronic Pain by Medical Approaches.t$$dNew York, NY : Springer New York,c2014$$z9781493918171
000724824 852__ $$bebk
000724824 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-1818-8$$zOnline Access$$91397441.1
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000724824 980__ $$aEBOOK
000724824 980__ $$aBIB
000724824 982__ $$aEbook
000724824 983__ $$aOnline
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