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Contributors; About the Editors; Part I: Basic Science in Cornea; Chapter 1: Oxidative Stress in℗ Cornea; 1.1 Oxidative Stress; 1.2 Oxidative Stress in℗ Cornea; 1.2.1 Antioxidant Defenses of℗ the℗ Tears, Aqueous Humor, and℗ Cornea; 1.2.2 Oxidative Stress as℗ a℗ Toxin; 1.2.2.1 Oxidative Damage; 1.2.2.2 Cell Arrest; 1.2.3 Oxidative Stress as℗ Signal Molecules; 1.2.3.1 Inflammation; 1.2.3.2 Proliferation; 1.2.3.3 Differentiation; 1.2.4 Other Corneal Diseases; References; Chapter 2: Corneal Degenerations; 2.1 Introduction; 2.2 Age-Related Corneal Degenerations; 2.2.1 Arcus Senilis
2.2.2 Vogt Limbal Girdle2.2.3 Crocodile Shagreen; 2.2.4 Peripheral Corneal Guttae; 2.3 Corneal Degenerations with℗ Tissue Thinning; 2.3.1 Terrien's Marginal Degeneration; 2.3.2 Dellen; 2.4 Corneal Degenerations with℗ Material Deposits; 2.4.1 Salzmann's Nodular Degeneration; 2.4.2 Band Keratopathy; 2.4.3 Lipid Keratopathy; 2.4.4 Spheroidal Keratopathy; 2.4.5 Vortex Keratopathy; 2.4.6 Pigment Deposition Keratopathies; 2.4.6.1 Pterygium; 2.4.6.2 Keratoconus; 2.4.6.3 Refractive Surgery; 2.5 Conclusions; References
Chapter 3: Corneal Epithelial Nuclear Ferritin and℗ Its Transporter Ferritoid Afford Unique Protection to℗ DNA from℗ UV Light and℗ Reactive Oxygen Species3.1 Introduction; 3.2 Free Iron and℗ UV-Induced Damage to℗ DNA; 3.3 Cytoplasmic Ferritin; 3.4 The Nuclear Ferritin of℗ Corneal Epithelial Cells; 3.5 The Role of℗ Nuclear Ferritin in℗ Protecting CE Cell DNA from℗ Damage by UV Radiation; 3.5.1 Protection from℗ Damage by Reactive Oxygen Species℗ (ROS); 3.6 Ferritoid: The℗ Nuclear Transporter for℗ CE Cell Ferritin; 3.6.1 Isolation of℗ a℗ cDNA for℗ Ferritoid and℗ its Tissue Specificity
3.6.2 Functional Analysis of℗ the℗ Nuclear Transport of℗ Ferritin by Ferritoid3.6.3 CE Nuclear Ferritin: A℗ Stable Heteropolymeric Ferritin-Ferritoid Complex with℗ Unique Properties; 3.6.4 Size(s) of℗ the℗ Ferritin-Ferritoid Complex(es); 3.6.5 Similarities of℗ the℗ CE Nuclear Ferritin-Ferritoid Complexes to℗ the℗ Bacterial DNA-Binding Proteins of℗ Starvation (Dps); 3.7 Developmental Analyses of℗ Ferritin and℗ Ferritoid; 3.7.1 Ferritin and℗ Ferritoid mRNAs During Development; 3.7.2 Ferritin and℗ Ferritoid Proteins During Development; 3.7.3 Developmental Regulation of℗ Ferritin and℗ Ferritoid
3.7.3.1 Systemic Factors3.7.3.2 Thyroxine as℗ a℗ Regulatory Factor; 3.7.4 Iron-Mediated Translational Regulation of℗ Ferritin and℗ Ferritoid; 3.7.5 The Ferritin-Ferritoid Interactions Required for℗ Nuclear Transport, Involve the℗ Phosphorylation of℗ Ferritoid; 3.7.6 Does the℗ CE of℗ the℗ Adult Cornea Have Ferritin-Ferritoid Complexes, and℗ Why Are They in℗ the℗ Embryo; References; Chapter 4: Excitatory Amino Acid Transporters, Xc- Antiporter, γ-Glutamyl Transpeptidase, Glutamine Synthetase, and℗ Glutathione in℗ Human Corneal Epithelial℗ Cells; 4.1 Introduction; 4.2 Materials and℗ Methods; 4.3 Results
2.2.2 Vogt Limbal Girdle2.2.3 Crocodile Shagreen; 2.2.4 Peripheral Corneal Guttae; 2.3 Corneal Degenerations with℗ Tissue Thinning; 2.3.1 Terrien's Marginal Degeneration; 2.3.2 Dellen; 2.4 Corneal Degenerations with℗ Material Deposits; 2.4.1 Salzmann's Nodular Degeneration; 2.4.2 Band Keratopathy; 2.4.3 Lipid Keratopathy; 2.4.4 Spheroidal Keratopathy; 2.4.5 Vortex Keratopathy; 2.4.6 Pigment Deposition Keratopathies; 2.4.6.1 Pterygium; 2.4.6.2 Keratoconus; 2.4.6.3 Refractive Surgery; 2.5 Conclusions; References
Chapter 3: Corneal Epithelial Nuclear Ferritin and℗ Its Transporter Ferritoid Afford Unique Protection to℗ DNA from℗ UV Light and℗ Reactive Oxygen Species3.1 Introduction; 3.2 Free Iron and℗ UV-Induced Damage to℗ DNA; 3.3 Cytoplasmic Ferritin; 3.4 The Nuclear Ferritin of℗ Corneal Epithelial Cells; 3.5 The Role of℗ Nuclear Ferritin in℗ Protecting CE Cell DNA from℗ Damage by UV Radiation; 3.5.1 Protection from℗ Damage by Reactive Oxygen Species℗ (ROS); 3.6 Ferritoid: The℗ Nuclear Transporter for℗ CE Cell Ferritin; 3.6.1 Isolation of℗ a℗ cDNA for℗ Ferritoid and℗ its Tissue Specificity
3.6.2 Functional Analysis of℗ the℗ Nuclear Transport of℗ Ferritin by Ferritoid3.6.3 CE Nuclear Ferritin: A℗ Stable Heteropolymeric Ferritin-Ferritoid Complex with℗ Unique Properties; 3.6.4 Size(s) of℗ the℗ Ferritin-Ferritoid Complex(es); 3.6.5 Similarities of℗ the℗ CE Nuclear Ferritin-Ferritoid Complexes to℗ the℗ Bacterial DNA-Binding Proteins of℗ Starvation (Dps); 3.7 Developmental Analyses of℗ Ferritin and℗ Ferritoid; 3.7.1 Ferritin and℗ Ferritoid mRNAs During Development; 3.7.2 Ferritin and℗ Ferritoid Proteins During Development; 3.7.3 Developmental Regulation of℗ Ferritin and℗ Ferritoid
3.7.3.1 Systemic Factors3.7.3.2 Thyroxine as℗ a℗ Regulatory Factor; 3.7.4 Iron-Mediated Translational Regulation of℗ Ferritin and℗ Ferritoid; 3.7.5 The Ferritin-Ferritoid Interactions Required for℗ Nuclear Transport, Involve the℗ Phosphorylation of℗ Ferritoid; 3.7.6 Does the℗ CE of℗ the℗ Adult Cornea Have Ferritin-Ferritoid Complexes, and℗ Why Are They in℗ the℗ Embryo; References; Chapter 4: Excitatory Amino Acid Transporters, Xc- Antiporter, γ-Glutamyl Transpeptidase, Glutamine Synthetase, and℗ Glutathione in℗ Human Corneal Epithelial℗ Cells; 4.1 Introduction; 4.2 Materials and℗ Methods; 4.3 Results