000724889 000__ 05230cam\a2200493Ii\4500 000724889 001__ 724889 000724889 005__ 20230306140556.0 000724889 006__ m\\\\\o\\d\\\\\\\\ 000724889 007__ cr\cn\nnnunnun 000724889 008__ 141217s2015\\\\sz\a\\\\ob\\\\001\0\eng\d 000724889 019__ $$a900887045$$a903985863$$a908083207 000724889 020__ $$a9783319099439$$qelectronic book 000724889 020__ $$a3319099434$$qelectronic book 000724889 020__ $$z9783319099422 000724889 0247_ $$a10.1007/978-3-319-09943-9$$2doi 000724889 035__ $$aSP(OCoLC)ocn898213764 000724889 035__ $$aSP(OCoLC)898213764$$z(OCoLC)900887045$$z(OCoLC)903985863$$z(OCoLC)908083207 000724889 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dOCLCF$$dIDEBK$$dEBLCP$$dVLB$$dE7B$$dCOO$$dYDXCP$$dDKU 000724889 049__ $$aISEA 000724889 050_4 $$aQP751$$b.L57 2015eb 000724889 08204 $$a612.397$$223 000724889 24500 $$aLipids and skin health$$h[electronic resource] /$$cApostolos Pappas, editor. 000724889 264_1 $$aCham :$$bSpringer,$$c[2015] 000724889 264_4 $$c©2015 000724889 300__ $$a1 online resource (x, 359 pages) :$$billustrations (some color) 000724889 336__ $$atext$$btxt$$2rdacontent 000724889 337__ $$acomputer$$bc$$2rdamedia 000724889 338__ $$aonline resource$$bcr$$2rdacarrier 000724889 504__ $$aIncludes bibliographical references and index. 000724889 5050_ $$aContributors; Part I; Editor's Introduction: Skin Lipids; Chapter 1; Skin Lipids: An Introduction and Their Importance; Part II; Skin Basics; Chapter 2; Skin Basics Structure and Function; Introduction; Functional Aspects of Skin in Health; Structural Organization of the Mammalian Skin; Epidermis; Diverse and Interdependent Barriers in Epidermis; The Dermal-Epidermal Junction (DEJ) or the Basement Membrane Zone (BMZ); The Dermis; Collagen; Elastin; Glycosaminoglycans (GAG); Fibroblasts; Other Components; Skin Appendages; Hypodermis; Summary of Skin Functions; References; Chapter 3 000724889 5058_ $$aSkin Barrier, Structure, and PropertiesIntroduction; History; Skin Lipid Composition and Phase State; Molecular Structure Determination Directly In Situ; The Procedure; CEMOVIS; Modeling and Simulation of the Horny Layer Lipid organization; Skin Lipid Structure; Skin Lipid Formation; Skin Lipid Function; Summary; References; Chapter 4; Polyunsaturated Fatty Acid Oxygenated Metabolites in Skin; Introduction; Cyclooxygenase-Derived Lipid Mediators; Lipoxygenase-Derived Lipid Mediators; Cytochrome P450-Derived Lipid Mediators; Non-enzymatically Produced Oxidised Lipid Mediators 000724889 5058_ $$aBioactivities of Oxidised Lipid Mediators and Role in Inflammatory Skin DiseaseBioactivity of Cutaneous Prostanoids; Bioactivity of Cutaneous Hydroxy and Epoxy Fatty Acids; References; Part III; Epidermal Lipids; Chapter 5; Skin Ceramides; Introduction; Biosynthetic Pathways; Structures, Proportions, and Properties; Catabolism; References; Chapter 6; Cholesterol Metabolism in the Epidermis; Introduction; Unraveling the Significance of Cholesterol for Skin Permeability Barrier Function; Effects of Aging; Cholesterol Sulfate; Role of Cholesterol Sulfate in Keratinocyte Differentiation 000724889 5058_ $$aSteroid SulfataseRole of Cholesterol Sulfate in Desquamation; Role of Cholesterol Sulfate in Permeability Function; Conclusion; References; Chapter 7; Nuclear Hormone Receptors and Epidermal Differentiation; Introduction; Keratinocyte Differentiation; Transcriptional Regulation of Keratinocyte Differentiation: Nuclear Hormone Receptors; Vitamin D Receptor (VDR); Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs); Peroxisome Proliferator-Activated Receptors (PPARs); Additional Remarks; Summary; References; Part IV; Sebaceous Lipids; Chapter 8; The Brain of the Skin: Sebaceous Gland 000724889 5058_ $$aIntroduction: The Birth of NeurodermatologyHormone Receptors in Human Sebaceous Glands and Their Biological Activity; Peptide Hormone and Neurotransmitter Receptors; Nuclear Receptors; Activation of the HPA-Like Skin Axis in Sebaceous Glands; Androgens and Sebaceous Gland Development, Cell Differentiation, and Lipogenesis; Signaling and Metabolic Pathways Operative in Hormonally Aged Sebocytes In Vitro; Conclusions; References; Chapter 9; Sebaceous Lipids; Introduction; Sebaceous Lipids and Their Uniqueness; a) Sapienic Acid; b) Wax Esters; c) Squalene 000724889 506__ $$aAccess limited to authorized users. 000724889 520__ $$aLipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin.℗ The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models t. 000724889 650_0 $$aLipids. 000724889 650_0 $$aSkin. 000724889 7001_ $$aPappas, Apostolos,$$eeditor. 000724889 77608 $$iPrint version:$$aPappas, Apostolos$$tLipids and Skin Health$$dCham : Springer International Publishing,c2014$$z9783319099422 000724889 852__ $$bebk 000724889 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-09943-9$$zOnline Access$$91397441.1 000724889 909CO $$ooai:library.usi.edu:724889$$pGLOBAL_SET 000724889 980__ $$aEBOOK 000724889 980__ $$aBIB 000724889 982__ $$aEbook 000724889 983__ $$aOnline 000724889 994__ $$a92$$bISE