000724954 000__ 05602cam\a2200553Li\4500 000724954 001__ 724954 000724954 005__ 20230306140600.0 000724954 006__ m\\\\\o\\d\\\\\\\\ 000724954 007__ cr\cn\nnnunnun 000724954 008__ 141211t20152015sz\a\\\\ob\\\\001\0\eng\d 000724954 019__ $$a904144564$$a908088403 000724954 020__ $$z9783319112794 000724954 020__ $$a9783319112800$$qelectronic book 000724954 020__ $$a3319112805$$qelectronic book 000724954 0247_ $$a10.1007/978-3-319-11280-0$$2doi 000724954 035__ $$aSP(OCoLC)ocn899000318 000724954 035__ $$aSP(OCoLC)899000318$$z(OCoLC)904144564$$z(OCoLC)908088403 000724954 040__ $$aE7B$$beng$$erda$$cE7B$$dOCLCO$$dYDXCP$$dCOO$$dGW5XE$$dOCLCF$$dIDEBK$$dUX0$$dDKU$$dEBLCP 000724954 049__ $$aISEA 000724954 05014 $$aQH650$$b.C435 2015eb 000724954 08204 $$a574.87$$223 000724954 1001_ $$aChakrabarti, Abhijit,$$eauthor. 000724954 24510 $$aBiochemical roles of eukaryotic cell surface macromolecules$$h[electronic resource] /$$cAbhijit Chakrabarti. 000724954 264_1 $$aCham, Switzerland :$$bSpringer,$$c2015. 000724954 264_4 $$c©2015 000724954 300__ $$a1 online resource (407 pages) :$$billustrations (some color), tables. 000724954 336__ $$atext$$2rdacontent 000724954 337__ $$acomputer$$2rdamedia 000724954 338__ $$aonline resource$$2rdacarrier 000724954 347__ $$atext file$$bPDF$$2rda 000724954 4901_ $$aAdvances in Experimental Medicine and Biology,$$x2214-8019 ;$$vVolume 842 000724954 504__ $$aIncludes bibliographical references and index. 000724954 5050_ $$aPreface; Contents; Chapter 1: Human-Specific Evolutionary Changes in the Biology of Siglecs; Introduction; Human-Specific Changes in Siglecs; Siglec-1/Sialoadhesin; Siglec-3/CD33; Siglec-5 and -14; Siglec-6; Siglec-9; Siglec-11 and -16; Siglec-XII; Siglec-13; Siglec-17; Conclusions and Perspectives; References; Chapter 2: Structural Changes of GPI Anchor After Its Attachment to Proteins: Functional Significance; Introduction; Biosynthesis of GPI and Its Attachment to Proteins; GPI Remodeling Reactions That Occur After Attachment to Proteins; Inositol-Deacylation by PGAP1 in the ER 000724954 5058_ $$aRemoval of an EtNP Side Branch from the Second Mannose by PGAP5 in the ER Fatty Acid Remodeling of GPI-AP in the Golgi; Biological Significance of Fatty Acid Remodeling; References; Chapter 3: Novel Insights in Membrane Biology Utilizing Fluorescence Recovery After Photobleaching; The Dynamic Membrane; Fluorescence Recovery After Photobleaching; Lipid Dynamics by FRAP; GPCR Activation: Manifestations in Receptor Dynamics; Dynamic Confinement of GPCRs Upon Cholesterol Depletion: Insight from Bleach Area-Dependent FRAP; Are Signaling and Dynamics Correlated? 000724954 5058_ $$aLateral Dynamics as Readout of Infection Conclusion and Future Perspectives; References; Chapter 4: Defects in Erythrocyte Membrane Skeletal Architecture; Introduction; Membrane Skeleton; Erythroid Membrane Skeleton; Lipid Bilayer: Membrane Skeleton Interactions; Assembly of the Membrane-Skeleton of Erythroid Cells; Defects in Membrane Skeleton; Hereditary Spherocytosis; Molecular Defects in HS; Pathophysiology; Laboratory Features and Treatment; Hereditary Elliptocytosis; Molecular Defects in HE; Laboratory Features and Treatment; Malaria and the Erythrocyte Membrane Skeleton Alterations 000724954 5058_ $$aConclusionReferences; Chapter 5: Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55; Introduction; Erythrocyte Membrane Rafts; Stomatin, Flotillins and MPP1 Are the Stable Components of Erythrocyte Rafts; Stomatin; Flotillins; MPP1; Visualization of Erythrocyte Membrane Rafts; Role of Erythrocyte Membrane Rafts in Signaling; Erythrocyte Rafts and Pathology; MPP1 and Its Palmitoylation Play a Crucial Role in Lateral Membrane Organization in Erythroid Cells; The Involvement of Actin in Erythrocyte Membrane Rafts Organization?; Conclusions; References 000724954 5058_ $$aChapter 6: Immuno-Modulatory Role of Porins: Host Immune Responses, Signaling Mechanisms and Vaccine PotentialIntroduction; Role of Porins in Modulation of Immune Responses; Innate Immune Responses; Adaptive Immune Response; Signaling Cascades Initiated by Porins; Porins as Vaccine Candidates; Conclusion; References; Chapter 7: Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical β-Barrel Pore-Forming Toxin; Introduction; Vibrio cholerae Cytolysin; Structural Features of VCC; Structural Features of the VCC β-Barrel Pore; Mechanism of Membrane Pore Formation; Conclusion 000724954 506__ $$aAccess limited to authorized users. 000724954 520__ $$aConsists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets. 000724954 588__ $$aDescription based on print version record. 000724954 650_0 $$aEukaryotic cells. 000724954 650_0 $$aMolecular biology. 000724954 650_0 $$aCell receptors. 000724954 77608 $$iPrint version:$$aChakrabarti, Abhijit.$$tBiochemical roles of eukaryotic cell surface macromolecules.$$dCham, Switzerland : Springer, c2015$$z9783319112794$$w(DLC) 2014955053 000724954 830_0 $$aAdvances in experimental medicine and biology ;$$vVolume 842. 000724954 852__ $$bebk 000724954 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-11280-0$$zOnline Access$$91397441.1 000724954 909CO $$ooai:library.usi.edu:724954$$pGLOBAL_SET 000724954 980__ $$aEBOOK 000724954 980__ $$aBIB 000724954 982__ $$aEbook 000724954 983__ $$aOnline 000724954 994__ $$a92$$bISE