000724983 000__ 03154cam\a2200493Ii\4500 000724983 001__ 724983 000724983 005__ 20230306140601.0 000724983 006__ m\\\\\o\\d\\\\\\\\ 000724983 007__ cr\cn\nnnunnun 000724983 008__ 150105s2015\\\\sz\a\\\\ob\\\\001\0\eng\d 000724983 019__ $$a903974255$$a908090341 000724983 020__ $$a9783319122328$$qelectronic book 000724983 020__ $$a3319122320$$qelectronic book 000724983 020__ $$z9783319122311 000724983 0247_ $$a10.1007/978-3-319-12232-8$$2doi 000724983 035__ $$aSP(OCoLC)ocn899211305 000724983 035__ $$aSP(OCoLC)899211305$$z(OCoLC)903974255$$z(OCoLC)908090341 000724983 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dCOO$$dOCLCF$$dN$T$$dIDEBK$$dCDX$$dE7B$$dEBLCP 000724983 049__ $$aISEA 000724983 050_4 $$aQM181 000724983 08204 $$a611.12$$223 000724983 1001_ $$aBittihn, Philip,$$eauthor. 000724983 24510 $$aComplex structure and dynamics of the heart$$h[electronic resource] /$$cPhilip Bittihn. 000724983 264_1 $$aCham :$$bSpringer,$$c2015. 000724983 300__ $$a1 online resource (xv, 204 pages) :$$billustrations (some color) 000724983 336__ $$atext$$btxt$$2rdacontent 000724983 337__ $$acomputer$$bc$$2rdamedia 000724983 338__ $$aonline resource$$bcr$$2rdacarrier 000724983 4901_ $$aSpringer Theses,$$x2190-5053 000724983 500__ $$a"Doctoral thesis accepted by the University of Göttingen, Germany." 000724983 504__ $$aIncludes bibliographical references and index. 000724983 5050_ $$aIntroduction -- Methods -- Results -- Conclusion -- Appendix A Modeling Details -- Appendix B Supplementary Data -- Appendix C MediaSim -- An Open Framework for Simulating Extended Systems -- Index. 000724983 506__ $$aAccess limited to authorized users. 000724983 520__ $$aThis award-winning thesis investigates the mechanisms underlying cardiac arrhythmia development and termination from an entirely new perspective. By viewing the heart as a complex system, the author uses theoretical tools from nonlinear dynamics combined with numerical simulations and experiments to achieve insights into the relationship between its structure and dynamics, thereby paving the way towards innovative low-energy defibrillation strategies. The work tackles, among other things: the effect of substrate heterogeneity on the spatial-temporal dynamics of cardiac arrhythmias and ways in which weak pulsed electric fields can be used to control these dynamics in heterogeneous cardiac tissue. The long-term vision of this research is to replace the current strategy of applying painful and sometimes tissue damaging electric shock ? currently the only reliable way to terminate life-threatening fibrillation ? by a more subtle but equally effective intervention. The book maps out a number of promising research directions for biophysicists and medical researchers working on the origins and treatment of cardiac arrhythmias. 000724983 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 14, 2015). 000724983 650_0 $$aHeart$$xAnatomy. 000724983 650_0 $$aHeart$$xMechanical properties. 000724983 650_0 $$aHeart$$xPhysiology. 000724983 77608 $$iPrint version:$$z9783319122311 000724983 830_0 $$aSpringer theses. 000724983 852__ $$bebk 000724983 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-12232-8$$zOnline Access$$91397441.1 000724983 909CO $$ooai:library.usi.edu:724983$$pGLOBAL_SET 000724983 980__ $$aEBOOK 000724983 980__ $$aBIB 000724983 982__ $$aEbook 000724983 983__ $$aOnline 000724983 994__ $$a92$$bISE