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000725136 019__ $$a903954434
000725136 020__ $$a9784431552123$$qelectronic book
000725136 020__ $$a443155212X$$qelectronic book
000725136 020__ $$z9784431552116
000725136 0247_ $$a10.1007/978-4-431-55212-3$$2doi
000725136 035__ $$aSP(OCoLC)ocn899987208
000725136 035__ $$aSP(OCoLC)899987208$$z(OCoLC)903954434
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000725136 049__ $$aISEA
000725136 050_4 $$aQP801.P638$$bP65 2015eb
000725136 08204 $$a572/.548$$223
000725136 24500 $$aPolyamines$$h[electronic resource] :$$ba universal molecular nexus for growth, survival, and specialized metabolism /$$cTomonobu Kusano, Hideyuki Suzuki, editors.
000725136 264_1 $$aTokyo :$$bSpringer,$$c2015.
000725136 300__ $$a1 online resource (ix, 336 pages) :$$billustrations.
000725136 336__ $$atext$$btxt$$2rdacontent
000725136 337__ $$acomputer$$bc$$2rdamedia
000725136 338__ $$aonline resource$$bcr$$2rdacarrier
000725136 500__ $$aIncludes index.
000725136 504__ $$aIncludes bibliographical references and index.
000725136 5050_ $$aPART I BIOSYNTHESIS OF POLYAMINES,- 1 Biosynthesis of Polyamines in Eukaryotes, Archaea, and Bacteria -- 2 Long-Chain and Branched Polyamines in Thermophilic Microbes -- 3 Regulation and Diversity of Polyamine Biosynthesis in Plants -- PART II CATABOLISM OF POLYAMINES -- 4 Polyamine Catabolism in Prokaryotes -- 5 Mammalian Polyamine Catabolism -- 6 Polyamine Catabolism in Plants -- PART III POLYAMINE HOMEOSTASIS -- 7 Antizyme -- 8 Bacterial Antizyme -- 9 Polyamine Homeostasis in Plants: The Role(s) of Evolutionarily Conserved Upstream ORFs -- PART IV ROLES OF POLYAMINES IN GROWTH -- 10 Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A -- 11 The Polyamine Modulon: Genes Encoding Proteins Whose Synthesis Is Enhanced by Polyamines at the Level of Translation -- 12 Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression -- PART V ROLES OF POLYAMINES IN SURVIVAL -- 13 Polyamines in Plant Stress Response -- PART VI POLYAMINE TRANSPORTERS -- 14 Recent Advances in Bacterial Polyamine Transport Systems -- 15 Polyamine Transport Systems in Plants -- PART VII POLYAMINE-DERIVED SECONDARY METABOLITES -- 16 Polyamine-Derived Alkaloids in Plants: Molecular Elucidation of Biosynthesis -- 17 Polyamine Toxins from Spiders and Wasps -- PART VIII ACTION OF POLYAMINES ON ION CHANNELS -- 18 Polyamine Block of Inwardly Rectifying Potassium (Kir) Channels -- 19 Polyamine Action on Plant Ion Channels and Pumps -- 20 Regulation of N-Methyl-d-Aspartate Receptors by Spermine and Ifenprodil -- PART IX POLYAMINES AND LONGEVITY -- 21 Polyamines and Longevity in Mammals -- 22 Polyamine Interactions with Plant Hormones: Crosstalk at Several Levels -- PART X DIAGNOSIS AND DRUG TARGETS -- 23 N1, N12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion -- 24 Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa.
000725136 506__ $$aAccess limited to authorized users.
000725136 520__ $$aThis book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.
000725136 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 26, 2015).
000725136 650_0 $$aPolyamines.
000725136 7001_ $$aKusano, Tomonobu,$$eeditor.
000725136 7001_ $$aSuzuki, Hideyuki,$$eeditor.
000725136 77608 $$iPrint version:$$z9784431552116
000725136 852__ $$bebk
000725136 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-4-431-55212-3$$zOnline Access$$91397441.1
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000725136 980__ $$aEBOOK
000725136 980__ $$aBIB
000725136 982__ $$aEbook
000725136 983__ $$aOnline
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