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000725340 019__ $$a908041811
000725340 020__ $$a9783319149141$$qelectronic book
000725340 020__ $$a3319149148$$qelectronic book
000725340 020__ $$z9783319149134
000725340 0247_ $$a10.1007/978-3-319-14914-1$$2doi
000725340 035__ $$aSP(OCoLC)ocn900723995
000725340 035__ $$aSP(OCoLC)900723995$$z(OCoLC)908041811
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000725340 049__ $$aISEA
000725340 050_4 $$aQA274.45$$b.X8 2015eb
000725340 08204 $$a519.2/3$$223
000725340 1001_ $$aXu, Jinbo,$$eauthor.
000725340 24510 $$aProtein homology detection through alignment of Markov random fields$$h[electronic resource] :$$busing MRFalign /$$cJinbo Xu, Sheng Wang, Jianzhu Ma.
000725340 264_1 $$aCham :$$bSpringer,$$c2015.
000725340 300__ $$a1 online resource (viii, 51 pages) :$$billustrations (some color).
000725340 336__ $$atext$$btxt$$2rdacontent
000725340 337__ $$acomputer$$bc$$2rdamedia
000725340 338__ $$aonline resource$$bcr$$2rdacarrier
000725340 4901_ $$aSpringerBriefs in Computer Science,$$x2191-5768
000725340 504__ $$aIncludes bibliographical references.
000725340 5050_ $$aIntroduction -- Method -- Software -- Experiments and Results -- Conclusion.
000725340 506__ $$aAccess limited to authorized users.
000725340 520__ $$aThis work covers sequence-based protein homology detection, a fundamental and challenging bioinformatics problem with a variety of real-world applications. The text first surveys a few popular homology detection methods, such as Position-Specific Scoring Matrix (PSSM) and Hidden Markov Model (HMM) based methods, and then describes a novel Markov Random Fields (MRF) based method developed by the authors. MRF-based methods are much more sensitive than HMM- and PSSM-based methods for remote homolog detection and fold recognition, as MRFs can model long-range residue-residue interaction. The text also describes the installation, usage and result interpretation of programs implementing the MRF-based method.
000725340 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 4, 2015).
000725340 650_0 $$aMarkov random fields.
000725340 650_0 $$aSequence alignment (Bioinformatics)
000725340 650_0 $$aBioinformatics.
000725340 7001_ $$aWang, Sheng,$$eauthor.
000725340 7001_ $$aMa, Jianzhu,$$eauthor.
000725340 77608 $$iPrint version:$$z9783319149134
000725340 830_0 $$aSpringerBriefs in computer science.
000725340 852__ $$bebk
000725340 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-14914-1$$zOnline Access$$91397441.1
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000725340 980__ $$aEBOOK
000725340 980__ $$aBIB
000725340 982__ $$aEbook
000725340 983__ $$aOnline
000725340 994__ $$a92$$bISE