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Contributors; Part I: Genetics/Genome/Microenvironment; Chapter 1: Diversity of Chromosomal Characteristics Among Mammals: With Special Reference to Laboratory Mouse in Cancer Resear...; 1.1 Introduction; 1.2 Do Large Size Mammals Have Longer and High Number of Chromosomes?; 1.3 Do X and Y Chromosomes Exist Intact in All Mammals?; 1.4 Distribution of Constitutive Heterochromatin in Mammalian Species; 1.5 Locations of Ribosomal Cistrons in Mammalian Chromosomes; 1.6 Distribution of Telomeric DNA in Mammalian Species
1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive
2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11q Deletion; 3.3.4 Trisomy 12; 3.4 Genomics of CLL; 3.4.1 WGS and WES; 3.4.1.1 NOTCH1; 3.4.1.2 SF3B1; 3.4.1.3 BIRC3; 3.4.1.4 XPO1; 3.4.1.5 MYD88; 3.4.1.6 Clonal Evolution in CLL
3.5 Transcriptome ProfilingReferences; Chapter 4: Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies; 4.1 Introduction; 4.2 Intrinsic and Extrinsic Factors Contribute to Biology of CLL Cells; 4.2.1 Intrinsic Factors: Genetic Aberrations in CLL; 4.2.2 Intrinsic Factors: Apoptotic Imbalance in CLL Cells; 4.2.3 Extrinsic Factors: Contribution of the Microenvironment to CLL Cell Survival; 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology; 4.3.1 B-cell Receptor, TNF Receptor Super Family, DED, and CARD Family
4.3.2 NF-kappaB, Caspase, and IAP Families4.3.3 Bcl-2 Family Antiapoptotic and Proapoptotic Proteins; 4.4 Microenvironment-Dependent Regulation of Apoptotic Pathway Proteins; 4.5 Therapeutic Strategies to Counter Survival Signals in CLL; 4.5.1 CLL Therapy: Standard of Care; 4.5.2 CLL Therapy: Targeting BCR Pathway; 4.5.3 CLL Therapy: Targeting Bcl-2 and IAPs; Conclusions; References; Chapter 5: Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside; 5.1 Introduction; 5.2 TAM Origin and Accumulation
1.7 Laboratory Mouse: Is the Animal Model or Muddle in Cancer Research1.8 Human Cloning and Producing Mini-Organs in Culture; References; Chapter 2: Genome-Based Multi-targeting of Cancer: Hype or Hope?; 2.1 Introduction; 2.2 Cancer Is an Age-Old Disease; 2.3 Cancer Is a Disease of Old Age; 2.4 Cancer Is More Common in Western/Developed Countries; 2.5 Cancer Is a Multigenic Disease; 2.6 Target-Specific Anticancer Drugs; 2.7 Anticancer Potential of Targeted Drugs; 2.8 Benefits of Most Targeted Drugs Is Marginal; 2.9 Most Targeted Drugs Are Highly Expensive
2.10 Adverse Effects Associated with Targeted Therapies2.11 Multi-targeted Drugs Derived from Mother Nature Are Needed; Conclusions; References; Chapter 3: Chronic Lymphocytic Leukemia at the Genomic Level; 3.1 Rai and Binet Staging; 3.2 IgVH Gene Mutation and ZAP-70 Status; 3.2.1 IgVH Mutation Status; 3.2.2 ZAP-70 Status; 3.3 Cytogenetic Abnormalities; 3.3.1 13q14 Deletion; 3.3.2 17p Deletion; 3.3.3 11q Deletion; 3.3.4 Trisomy 12; 3.4 Genomics of CLL; 3.4.1 WGS and WES; 3.4.1.1 NOTCH1; 3.4.1.2 SF3B1; 3.4.1.3 BIRC3; 3.4.1.4 XPO1; 3.4.1.5 MYD88; 3.4.1.6 Clonal Evolution in CLL
3.5 Transcriptome ProfilingReferences; Chapter 4: Apoptosis Pathways in Chronic Lymphocytic Leukemia: Role of the Microenvironment and Therapeutic Strategies; 4.1 Introduction; 4.2 Intrinsic and Extrinsic Factors Contribute to Biology of CLL Cells; 4.2.1 Intrinsic Factors: Genetic Aberrations in CLL; 4.2.2 Intrinsic Factors: Apoptotic Imbalance in CLL Cells; 4.2.3 Extrinsic Factors: Contribution of the Microenvironment to CLL Cell Survival; 4.3 Role of Apoptosis Pathway Members in CLL Pathophysiology; 4.3.1 B-cell Receptor, TNF Receptor Super Family, DED, and CARD Family
4.3.2 NF-kappaB, Caspase, and IAP Families4.3.3 Bcl-2 Family Antiapoptotic and Proapoptotic Proteins; 4.4 Microenvironment-Dependent Regulation of Apoptotic Pathway Proteins; 4.5 Therapeutic Strategies to Counter Survival Signals in CLL; 4.5.1 CLL Therapy: Standard of Care; 4.5.2 CLL Therapy: Targeting BCR Pathway; 4.5.3 CLL Therapy: Targeting Bcl-2 and IAPs; Conclusions; References; Chapter 5: Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside; 5.1 Introduction; 5.2 TAM Origin and Accumulation