Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells [electronic resource] : mathematical modeling and experimental observations / Iman Tavassoly.

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Dynamics of cell fate decision mediated by the interplay of autophagy and apoptosis in cancer cells [electronic resource] : mathematical modeling and experimental observations / Iman Tavassoly.

9783319149622 electronic book
3319149628 electronic book
9783319149615

Cham : Springer, [2015]

©2015

English

1 online resource : color illustrations.

10.1007/978-3-319-14962-2 doi

QL963.5 .T38 2015eb

571.8636

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative℗ℓfluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

Includes bibliographical references.

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Description based on online resource; title from PDF title page (viewed February 23, 2015).

Springer theses.

Print version: 9783319149615

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