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000725787 019__ $$a908098323
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000725787 24500 $$aHypoparathyroidism$$h[electronic resource] /$$cMaria Luisa Brandi, Edward Meigs Brown, editor.
000725787 264_1 $$aMilan ;$$aHeidelberg ;$$aNew York :$$bSpringer,$$c[2015]
000725787 264_4 $$c©2015
000725787 300__ $$a1 online resource
000725787 336__ $$atext$$btxt$$2rdacontent
000725787 337__ $$acomputer$$bc$$2rdamedia
000725787 338__ $$aonline resource$$bcr$$2rdacarrier
000725787 504__ $$aIncludes bibliographical references and index.
000725787 5050_ $$aForeword; Preface; Contents; Contributors; Part I: Anatomy and Physiology of the Parathyroid Glands; 1: The History: From℗ Ivar Sandstr©œm to℗ the℗ Sequence of℗ Parathyroid Hormone; 1.1 Introduction; 1.2 Discovery of℗ the℗ Glands; 1.3 Clarification of℗ the℗ Separate Anatomy of℗ the℗ Parathyroids; 1.4 Physiological Role of℗ the℗ Glands; 1.5 The Parathyroids Are Endocrine Glands; 1.6 Era of℗ Chemical Biology; 1.7 Era of℗ Molecular Biology; References; 2: Embryology of℗ the℗ Parathyroid Glands; 2.1 Introduction; 2.2 Anatomy of℗ Parathyroid Organogenesis
000725787 5058_ $$a2.3 Molecular Regulators of℗ Initial Parathyroid Specification2.3.1 Transcription Factors; 2.3.2 Signaling Pathways; 2.4 Differentiation and℗ Survival of℗ Parathyroids: Gcm2; 2.5 The Thymus-Parathyroid Connection; 2.5.1 Do the℗ Thymus and℗ Parathyroids Have Overlapping Functions?; 2.5.2 Stability of℗ Parathyroid Cell℗ Fate; References; 3: PTH and℗ PTH-Related Peptides; 3.1 Introduction; 3.2 PTH and℗ PTHrP: Genes, Structures, and℗ Biosynthesis; 3.3 Regulation, Metabolism, and℗ Catabolism of℗ PTH and℗ PTHrP; 3.4 Receptor and℗ Biological Effects of℗ PTH and℗ PTHrP; References
000725787 5058_ $$a4: PTH Assays and℗ Their Clinical Significance4.1 Introduction; 4.2 Origin of℗ Circulating PTH Molecular Forms; 4.3 Molecular Forms of℗ PTH in℗ Specific Clinical Conditions; 4.3.1 Primary Hyperparathyroidism; 4.3.2 Hypoparathyroidism; 4.3.3 Non-parathyroid Hypercalcemia; 4.3.4 Secondary Hyperparathyroidism Related to℗ Vitamin D Deficiency; 4.3.5 Renal Failure; Conclusion; References; 5: Control of℗ Parathyroid Hormone Secretion by Extracellular Ca2+; 5.1 Introduction; 5.2 Role of℗ PTH in℗ Maintaining Mineral Ion Homeostasis In℗ Vivo; 5.3 Mechanisms That Determine the℗ Overall Rate of℗ PTH Secretion
000725787 5058_ $$a5.3.1 Production of℗ PTH-Containing Secretory Vesicles5.3.2 The Physiology of℗ Ca2+o-℗ƯRegulated PTH Secretion; 5.4 Mechanisms by Which Ca2+o Regulates the℗ Diverse Aspects of℗ Parathyroid Function That Determine the℗ Overall Rate of℗ PTH Release; 5.4.1 Molecular Basis for℗ Ca2+o-Sensing; 5.4.2 The CaSR Is the℗ Mediator of℗ the℗ Regulation of℗ PTH Secretion by Ca2+o; 5.4.3 The CaSR Can Modulate PTH Secretion Independent of℗ Changes in℗ Ca2+o; 5.4.4 Control of℗ PTH Degradation by Ca2+o and℗ the℗ CaSR; 5.4.5 Role of℗ the℗ CaSR in℗ Regulating PTH Gene Expression
000725787 5058_ $$a5.4.6 Ca2+o Regulates Parathyroid Cellular Proliferation via the℗ CaSR5.4.7 Does the℗ CaSR Modulate Parathyroid Cell Apoptosis?; Conclusions; References; 6: Phosphate Control of℗ PTH Secretion; 6.1 Introduction; 6.2 General Notes on℗ Phosphorus Metabolism; 6.2.1 Main Functions and℗ Body Distribution of℗ Phosphorus; 6.2.2 Factors Controlling Phosphate Metabolism; 6.2.3 Phosphorus Control of℗ Its Controlling Factors; 6.2.3.1 PTH-Mediated Phosphate Control; 6.2.3.2 Phosphate-Mediated Control of℗ Parathyroid Function; 6.2.4 Indirect Effects of℗ Pi on℗ PTH; 6.2.5 Direct Effects of℗ Phosphate on℗ PTH
000725787 506__ $$aAccess limited to authorized users.
000725787 520__ $$aHypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the ℗ℓpublication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority. Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH ℗ℓpeptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians. ℗ℓ
000725787 650_0 $$aParathyroid hormone.
000725787 650_0 $$aParathyroid glands$$xDiseases.
000725787 7001_ $$aBrandi, M. L.$$q(Maria Luisa),$$eeditor.
000725787 7001_ $$aBrown, Edward M.$$q(Edward Meigs),$$eeditor.
000725787 77608 $$iPrint version:$$aBrandi, Maria Luisa$$tHypoparathyroidism$$dDordrecht : Springer,c2015$$z9788847053755
000725787 852__ $$bebk
000725787 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-88-470-5376-2$$zOnline Access$$91397441.1
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