Single cell sequencing and systems immunology [electronic resource] / Xiangdong Wang, editor ; honor editors, Xiaoming Chen, Zhihong Sun, Jinglin Xia.

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Single cell sequencing and systems immunology [electronic resource] / Xiangdong Wang, editor ; honor editors, Xiaoming Chen, Zhihong Sun, Jinglin Xia.

9789401797535 electronic book
9401797536 electronic book
9789401797528

Dordrecht : Springer, [2015]

©2015

English

1 online resource : illustrations.

10.1007/978-94-017-9753-5 doi

QR182.2.I46

571.960285

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

Includes bibliographical references.

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Description based on online resource; title from PDF title page (viewed April 1, 2015).

Translational bioinformatics ; volume 5.

Print version: 9789401797528

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