000726740 000__ 03152cam\a2200481Ii\4500
000726740 001__ 726740
000726740 005__ 20230306140836.0
000726740 006__ m\\\\\o\\d\\\\\\\\
000726740 007__ cr\cn\nnnunnun
000726740 008__ 150427s2015\\\\enka\\\\ob\\\\001\0\eng\d
000726740 020__ $$a9783319185187$$qelectronic book
000726740 020__ $$a3319185187$$qelectronic book
000726740 020__ $$z9783319185170
000726740 0247_ $$a10.1007/978-3-319-18518-7$$2doi
000726740 035__ $$aSP(OCoLC)ocn908030604
000726740 035__ $$aSP(OCoLC)908030604
000726740 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dYDXCP$$dIDEBK$$dCDX$$dCOO$$dUPM$$dOCLCO$$dEBLCP
000726740 049__ $$aISEA
000726740 050_4 $$aRA643.8
000726740 08204 $$a614.5/99392$$223
000726740 24504 $$aThe future of HIV-1 therapeutics$$h[electronic resource] :$$bresistance is futile? /$$cBruce E. Torbett, David S. Goodsell, Douglas D. Richman, editors.
000726740 264_1 $$aLondon :$$bSpringer,$$c2015.
000726740 300__ $$a1 online resource :$$bcolor illustrations
000726740 336__ $$atext$$btxt$$2rdacontent
000726740 337__ $$acomputer$$bc$$2rdamedia
000726740 338__ $$aonline resource$$bcr$$2rdacarrier
000726740 4901_ $$aCurrent topics in microbiology and immunology ;$$vvolume 389
000726740 504__ $$aIncludes bibliographical references and index.
000726740 5050_ $$aHIV Therapy ? Looking Towards the Future -- Computational challenges of structure-based approaches applied to HIV -- Nucleocapsid Protein: A Desirable Target For Future Therapies Against HIV-1 -- HIV-1 integrase multimerization as a therapeutic target -- Targeting HIV transcription: The quest for a functional cure -- Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder -- HIV-1 Gag: An Emerging Target for Antiretroviral Therapy -- The Triple Threat of HIV-1 Protease Inhibitors -- Illustrations of the HIV Life Cycle.
000726740 506__ $$aAccess limited to authorized users.
000726740 520__ $$aThis volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. The individual chapters will appeal to scientists and clinicians alike.
000726740 650_0 $$aAntiviral agents.
000726740 650_0 $$aHIV infections$$xPrevention.
000726740 650_0 $$aHIV antibodies.
000726740 7001_ $$aTorbett, Bruce E.,$$eeditor.
000726740 7001_ $$aGoodsell, David S.,$$eeditor.
000726740 7001_ $$aRichman, Douglas D.,$$eeditor.
000726740 77608 $$iPrint version:$$tFuture of HIV-1 therapeutics : resistance is futile?.$$dNew York, New York : Springer, [2015]$$z9783319185170$$w(DLC)18554653
000726740 830_0 $$aCurrent topics in microbiology and immunology ;$$v389.
000726740 852__ $$bebk
000726740 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-18518-7$$zOnline Access$$91397441.1
000726740 909CO $$ooai:library.usi.edu:726740$$pGLOBAL_SET
000726740 980__ $$aEBOOK
000726740 980__ $$aBIB
000726740 982__ $$aEbook
000726740 983__ $$aOnline
000726740 994__ $$a92$$bISE