Biomolecular interfaces [electronic resource] : interactions, functions and drug design / Ariel Fernández Stigliano.
Fernández Stigliano, Ariel, author.
2015
QP514.2 .F47 2015eb
Available Online

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Title Biomolecular interfaces [electronic resource] : interactions, functions and drug design / Ariel Fernández Stigliano.
Author Fernández Stigliano, Ariel, author.
ISBN 9783319168500 electronic book
3319168509 electronic book
9783319168494
DOI https://doi.org/10.1007/978-3-319-16850-0
Published Cham : Springer, 2015.
Language English
Description 1 online resource (xix, 372 pages) : illustrations.
Item Number 10.1007/978-3-319-16850-0 doi
Call Number QP514.2 .F47 2015eb
Dewey Decimal Classification 572/.33
Summary The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed May 1, 2015).
Available in Other Form Print version: 9783319168494
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The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology
Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water
Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches
Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface
Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation
Evolution of Protein Structure Degradation and Lessons for the Drug Designer
Chemical Functionality of the Aqueous Interface in Soluble Proteins
The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy
Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer
Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine
Controlling Induced Folding Through Wrapping Drug Design
Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology
Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology
Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment
High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design
Epilogue
Appendix 1. Code for Dehydron Identification
Appendix 2. Solutions of Problems.

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