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000727104 020__ $$a9789401799270$$qelectronic book
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000727104 049__ $$aISEA
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000727104 08204 $$a616.042$$223
000727104 24500 $$aComputational and statistical epigenomics$$h[electronic resource] /$$cAndrew E. Teschendorff, editor.
000727104 264_1 $$aDordrecht [Netherlands] :$$bSpringer,$$c[2015]
000727104 300__ $$a1 online resource.
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000727104 337__ $$acomputer$$bc$$2rdamedia
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000727104 4901_ $$aTranslational bioinformatics ;$$vVolume 7
000727104 504__ $$aIncludes bibliographical references.
000727104 506__ $$aAccess limited to authorized users.
000727104 520__ $$aThis book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike. Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.
000727104 650_0 $$aEpigenetics$$xMathematical models.
000727104 7001_ $$aTeschendorff, Andrew E.,$$eeditor.
000727104 830_0 $$aTranslational bioinformatics ;$$vVolume 7.
000727104 85280 $$bebk$$hSpringerLink
000727104 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-94-017-9927-0$$zOnline Access$$91397441.1
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000727104 980__ $$aEBOOK
000727104 980__ $$aBIB
000727104 982__ $$aEbook
000727104 983__ $$aOnline
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