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Title
Hyperbranched polydendrons [electronic resource] : a new macromolecular architecture / Fiona L. Hatton.
ISBN
9783319187532 electronic book
3319187538 electronic book
9783319187525
Published
Cham : Springer, [2015]
Copyright
©2015
Language
English
Description
1 online resource (xxii, 260 pages) : illustrations.
Item Number
10.1007/978-3-319-18753-2 doi
Call Number
QD382.B73 H37 2015eb
Dewey Decimal Classification
547/.7
Summary
This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles ? a research goal that is currently being pursued by several groups around the globe.
Note
"Doctoral thesis accepted by the University of Liverpool, UK."
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed May 22, 2015).
Series
Springer theses.
Available in Other Form
Print version: 9783319187525
Introduction
Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation
Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation
Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles
Hyp-Polydendrons; studies of nanoprecipitation behavior
Conclusions and Future work
Experimental.
