000727185 000__ 03321cam\a2200481Ii\4500
000727185 001__ 727185
000727185 005__ 20230306140804.0
000727185 006__ m\\\\\o\\d\\\\\\\\
000727185 007__ cr\cn\nnnunnun
000727185 008__ 150519s2015\\\\sz\a\\\\ob\\\\000\0\eng\d
000727185 020__ $$a9783319187532$$qelectronic book
000727185 020__ $$a3319187538$$qelectronic book
000727185 020__ $$z9783319187525
000727185 0247_ $$a10.1007/978-3-319-18753-2$$2doi
000727185 035__ $$aSP(OCoLC)ocn909368005
000727185 035__ $$aSP(OCoLC)909368005
000727185 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dN$T$$dIDEBK$$dYDXCP$$dE7B$$dNUI$$dCOO$$dEBLCP$$dVLB
000727185 049__ $$aISEA
000727185 050_4 $$aQD382.B73$$bH37 2015eb
000727185 08204 $$a547/.7$$223
000727185 1001_ $$aHatton, Fiona L.,$$eauthor.
000727185 24510 $$aHyperbranched polydendrons$$h[electronic resource] :$$ba new macromolecular architecture /$$cFiona L. Hatton.
000727185 264_1 $$aCham :$$bSpringer,$$c[2015]
000727185 264_4 $$c©2015
000727185 300__ $$a1 online resource (xxii, 260 pages) :$$billustrations.
000727185 336__ $$atext$$btxt$$2rdacontent
000727185 337__ $$acomputer$$bc$$2rdamedia
000727185 338__ $$aonline resource$$bcr$$2rdacarrier
000727185 4901_ $$aSpringer theses,$$x2190-5053
000727185 500__ $$a"Doctoral thesis accepted by the University of Liverpool, UK."
000727185 504__ $$aIncludes bibliographical references.
000727185 5050_ $$aIntroduction -- Synthesis and characterisation of hyp-polydendron materials and subsequent anoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and aqueous nanoparticle formation -- Mixing dendron and PEG initiators for the polymerisation of branched pHPMA and formation of sterically stabilised nanoparticles -- Hyp-Polydendrons; studies of nanoprecipitation behavior -- Conclusions and Future work -- Experimental.
000727185 506__ $$aAccess limited to authorized users.
000727185 520__ $$aThis thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles ? a research goal that is currently being pursued by several groups around the globe.
000727185 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed May 22, 2015).
000727185 650_0 $$aBranched polymers.
000727185 650_0 $$aDendrimers.
000727185 77608 $$iPrint version:$$z9783319187525
000727185 830_0 $$aSpringer theses.
000727185 852__ $$bebk
000727185 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-18753-2$$zOnline Access$$91397441.1
000727185 909CO $$ooai:library.usi.edu:727185$$pGLOBAL_SET
000727185 980__ $$aEBOOK
000727185 980__ $$aBIB
000727185 982__ $$aEbook
000727185 983__ $$aOnline
000727185 994__ $$a92$$bISE