Behavioral neurobiology of Huntington's disease and Parkinson's disease [electronic resource] / Hoa Huu Phuc Nguyen, M. Angela Cenci, editors.
Nguyen, Hoa Huu Phuc, editor.; Cenci, M. Angela, editor.
2015
RC346
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title Behavioral neurobiology of Huntington's disease and Parkinson's disease [electronic resource] / Hoa Huu Phuc Nguyen, M. Angela Cenci, editors.
ISBN 9783662463444 electronic book
366246344X electronic book
9783662463437
Published Heidelberg : Springer, [2015]
Language English
Description 1 online resource : illustrations (mostly color).
Call Number RC346
Dewey Decimal Classification 616.8
Summary Motor dysfunction and cognitive impairment are major symptoms in both Huntington's Disease (HD) and Parkinson's Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to cause familial forms of PD. Following these genetic discoveries, a variety of genetic disease models were generated, providing completely novel opportunities to explore the neurobiological basis of HD and PD. Genetic models allow us to study the earliest manifestations of the diseases both behaviorally and neuropathologically, and provide tools to probe molecular pathways of neurodegeneration. Additionally, neurotoxic animal models allow us to reproduce neurochemical and cellular events of great pathophysiological importance. In the PD field, neurotoxic animal models remain the preferred option to reproduce symptomatic features of the human disease that are responsive to dopaminergic pharmacotherapies. In addition, neurotoxic PD models are often used to investigate pathways of mitochondrial dysfunction, oxidative stress, and neuroinflammation. This book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed May 29, 2015).
Added Author Nguyen, Hoa Huu Phuc, editor.
Cenci, M. Angela, editor.
Series Current topics in behavioral neurosciences ; v. 22.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Clinical Aspects of Huntington's Disease
The Neuropathology of Huntington's Disease
Neurobiology of Huntington's Disease
Mouse Models of Huntington's Disease
Transgenic Rat Models of Huntington's Disease
Large Animal Models of Huntington's Disease
Therapeutic Strategies for Huntington's Disease
Clinical and Pathological Features of Parkinson?s Disease
Symptomatic Models of Parkinson?s Disease and L-DOPA-Induced Dyskinesia in Non-human Primates
Neuroinflammation in Parkinson?s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?
Viral Vector-Based Models of Parkinson's Disease
Transgenic Rodent Models to Study Alpha-Synuclein Pathogenesis, with a Focus on Cognitive Deficits
Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents
Models of Multiple System Atrophy.

Browse Subjects

Show more subjects...

Statistics

from
to
Export