000727313 000__ 02925cam\a2200469Ii\4500 000727313 001__ 727313 000727313 005__ 20230306140812.0 000727313 006__ m\\\\\o\\d\\\\\\\\ 000727313 007__ cr\cn\nnnunnun 000727313 008__ 150527s2015\\\\ne\\\\\\o\\\\\000\0\eng\d 000727313 019__ $$a910630140 000727313 020__ $$a9789401772129$$qelectronic book 000727313 020__ $$a9401772126$$qelectronic book 000727313 020__ $$z9789401772112 000727313 0247_ $$a10.1007/978-94-017-7212-9$$2doi 000727313 035__ $$aSP(OCoLC)ocn910159385 000727313 035__ $$aSP(OCoLC)910159385$$z(OCoLC)910630140 000727313 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dOCLCO$$dIDEBK$$dGW5XE$$dYDXCP$$dE7B$$dNUI$$dEBLCP$$dCDX 000727313 049__ $$aISEA 000727313 050_4 $$aQH465.E58 000727313 08204 $$a572.86 000727313 1001_ $$aZhang, Huidong,$$eauthor. 000727313 24510 $$aDNA replication$$h[electronic resource] :$$bdamage from environmental carcinogens /$$cHuidong Zhang. 000727313 264_1 $$aDordrecht :$$bSpringer,$$c2015. 000727313 300__ $$a1 online resource :$$billustrations 000727313 336__ $$atext$$btxt$$2rdacontent 000727313 337__ $$acomputer$$bc$$2rdamedia 000727313 338__ $$aonline resource$$bcr$$2rdacarrier 000727313 4901_ $$aSpringerBriefs in biochemistry and molecular biology,$$x2211-9361 000727313 504__ $$aIncludes bibliographical references and index. 000727313 5050_ $$aDNA replication -- Disturbances of the DNA replication system -- Fate of DNA replisome upon encountering DNA damage -- External Causes for DNA Damage -- Effect of environmental carcinogens on cellular physiology -- Protocols for studies of bypass of DNA damage by DNA polymerase. 000727313 506__ $$aAccess limited to authorized users. 000727313 520__ $$aThis book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health. 000727313 588__ $$aOnline resource; title from PDF title page (viewed June 1, 2015). 000727313 650_0 $$aDNA damage. 000727313 650_0 $$aDNA replication. 000727313 650_0 $$aCarcinogens. 000727313 830_0 $$aSpringerBriefs in biochemistry and molecular biology. 000727313 852__ $$bebk 000727313 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-94-017-7212-9$$zOnline Access$$91397441.1 000727313 909CO $$ooai:library.usi.edu:727313$$pGLOBAL_SET 000727313 980__ $$aEBOOK 000727313 980__ $$aBIB 000727313 982__ $$aEbook 000727313 983__ $$aOnline 000727313 994__ $$a92$$bISE