000727505 000__ 05138cam\a2200481Ii\4500 000727505 001__ 727505 000727505 005__ 20230306140924.0 000727505 006__ m\\\\\o\\d\\\\\\\\ 000727505 007__ cr\cn\nnnunnun 000727505 008__ 150608s2015\\\\sz\\\\\\o\\\\\000\0\eng\d 000727505 019__ $$a914151061 000727505 020__ $$a9783319160566$$qelectronic book 000727505 020__ $$a3319160567$$qelectronic book 000727505 020__ $$z9783319160559 000727505 035__ $$aSP(OCoLC)ocn910845410 000727505 035__ $$aSP(OCoLC)910845410$$z(OCoLC)914151061 000727505 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dGW5XE$$dIDEBK$$dYDXCP$$dEBLCP 000727505 049__ $$aISEA 000727505 050_4 $$aRM292.2 000727505 08204 $$a615.3/64$$223 000727505 24500 $$aSystemic corticosteroids for inflammatory disorders in pediatrics$$h[electronic resource] /$$cRolando Cimaz, editor. 000727505 264_1 $$aCham :$$bAdis,$$c[2015] 000727505 300__ $$a1 online resource. 000727505 336__ $$atext$$btxt$$2rdacontent 000727505 337__ $$acomputer$$bc$$2rdamedia 000727505 338__ $$aonline resource$$bcr$$2rdacarrier 000727505 504__ $$aIncludes bibliographical references. 000727505 5050_ $$aSystemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Introduction; References; Corticosteroids in the Treatment of Childhood Rheumatic Diseases: A Historical Review; The Origins of Corticosteroid Therapy; Corticosteroids in the Treatment of Childhood Arthritis; Corticosteroids in Treatment of Connective Tissue Diseases of Childhood; Pursuit of Efficacy with Minimal Toxicity; Summary; References; Systemic Corticosteroids for Autoimmune/Inflammatory Disorders in Children: Clinical Aspects; Introduction; Mechanisms of Action; Pharmacology 000727505 5058_ $$aConditions of Prescription and Main Indications (Table 2) How to Limit the Main Side Effects of GCs; Metabolic Complications; Osteoporosis; Growth-Retarding Effects; Infections; Psychiatric Disturbances; Conclusion; References; The Molecular and Cellular Mechanisms Responsible for the Anti-inflammatory and Immunosuppressive Effects of Glucocorticoids; Introduction; Molecular Mechanisms of Glucocorticoids; Genomic Effects; Upregulation of Gene Transcription; Downregulation of Gene Transcription; Downregulation of Gene Transcription by GR-Dependent Upregulation of Inhibitory Factors 000727505 5058_ $$aNongenomic Effects GC-Activated Anti-inflammatory and Immunosuppressive Pathways; Effects on T Lymphocytes; Effects on Regulatory T Cells; Effects on Effector T Cells; Effects on Thymocytes; Effects on the Cells of Innate Immunity; Conclusions; References; The Clinical Pharmacology of Past, Present, and Future Glucocorticoids; Introduction; Past, Present, and Future GCs; Old GCs; New Generation of Topical GCs; Selective GR Agonists; Long-Circulating Liposomal GCs and Other Reformulations of Old GCs; Intersubjective Variability in the Response to GCs; Genetic Resistance to GCs 000727505 5058_ $$aAcquired Resistance to GCs GCs and Gender; Molecular Basis of GC Interactions; Synergism in the Treatment of Asthmatic Patients; Pharmacokinetic Interactions; Conclusions; References; Corticosteroids in Juvenile Idiopathic Arthritis; The Use of Corticosteroids in the Treatment of Juvenile Idiopathic Arthritis; Corticosteroids in the Different JIA Categories; Systemic JIA; Polyarticular JIA; Oligoarticular JIA; Juvenile Psoriatic Arthritis; Enthesitis-Related Arthritis; Corticosteroids in MAS; Corticosteroids in JIA-Related Uveitis; Intra-articular Corticosteroid Therapy in JIA 000727505 5058_ $$aConclusionsReferences; Systemic Corticosteroids in Childhood Vasculitides; Introduction; Henoch-Schönlein Purpura; Clinical Manifestations; Cutaneous Involvement; Arthritis; Gastrointestinal Manifestations; Renal Disease; Treatment; Prognosis; Kawasaki Disease; Clinical Manifestations; Treatment; Polyarteritis Nodosa; Treatment; Takayasu Arteritis; Treatment; ANCA-Associated Vasculitides; Treatment; Central Nervous System Vasculitis; Treatment; References; Corticosteroids in Pediatric-Onset SLE and Other Connective Tissue Diseases; Introduction 000727505 506__ $$aAccess limited to authorized users. 000727505 520__ $$aThis comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids st. 000727505 650_0 $$aAdrenocortical hormones$$xTherapeutic use. 000727505 650_0 $$aAdrenocortical hormones$$xEffectiveness. 000727505 650_0 $$aPediatrics. 000727505 7001_ $$aCimaz, Rolando,$$eeditor. 000727505 77608 $$iPrint version:$$aCimaz, Rolando$$tSystemic Corticosteroids for Inflammatory Disorders in Pediatrics$$dCham : Springer International Publishing,c2015$$z9783319160559 000727505 852__ $$bebk 000727505 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-16056-6$$zOnline Access$$91397441.1 000727505 909CO $$ooai:library.usi.edu:727505$$pGLOBAL_SET 000727505 980__ $$aEBOOK 000727505 980__ $$aBIB 000727505 982__ $$aEbook 000727505 983__ $$aOnline 000727505 994__ $$a92$$bISE