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Contributors; Part I ; Introduction; Chapter-1; Otitis Media Concepts, Facts, and Fallacies; Introduction; Definitions; Epidemiology and Risk Factors; Age; Pathogenesis; Eustachian Tube Anatomy; Microbiology; Bacterial Resistance Patterns; Diagnosis; Tympanometry; Tympanocentesis; Acoustic Reflexometry; Treatment; Conservative Management and Observation; Surgical Treatment; Myringotomy and Insertion of Tympanostomy Tubes; Post-myringotomy Tube Otorrhea; Surgical Treatment for Chronic OME; References; Part II ; Concepts and Diagnosis; Chapter-2
Epidemiology of Otitis Media: What Have We Learned from the New Century Global Health DisparitiesIntroduction; Global Health Disparities; Conclusion; References; Chapter-3; Impact of Genetic Background in Otitis Media Predisposition; Twin Studies; Linkage Analysis Studies; Candidate Gene Approach; Animal Models; References; Chapter-4; Risk Factors for Recurrent Acute Otitis Media and Chronic Otitis Media with Effusion in Childhood; Host-associated Risk Factors for RAOM; Allergy; Craniofacial Abnormalities; Gastroesophageal Reflux (GER); Adenoids; Genetic Susceptibility
Environmental Risk Factors for RAOMUpper Respiratory Tract Infections (URTI); Day-care Center Attendance; Family Size (Siblings); Passive Smoking; Breast-feeding; Use of Pacifier; References; Chapter-5; Microbiology, Antimicrobial Susceptibility, and Antibiotic Treatment; Introduction; Microbiology; Virus; Viral-Bacterial Interactions; Bacteriology; Polymicrobial Interactions; Implications of Bacterial Vaccine Efforts for Practice ; Bacterial Susceptibility to Antibiotics; Antibiotic Therapy; Initial Antibiotic Treatment Failure; Duration of Therapy; Conclusion; References; Chapter-6
Abnormal Innate and Adaptive Immunity in Otitis MediaAdvances in Potential Bench to Bedside in OM Research; References; Chapter-7; Basic Science Concepts in Otitis Media Pathophysiology and Immunity: Role of Mucins and Inflammation; Part I: The Innate Immunity in Otitis Media; The First Line of Defense of the Innate Immunity: Cellular and Humoral Barriers; The Middle Ear Epithelium; The Mucus in the Middle Ear: An Important Role for Mucins; Antimicrobial Molecules in Effusions; Recognition of Pathogens; The System of the Complement; Receptors of the Innate Immunity
Role of the Inflammation in OMPro-inflammatory Cytokines and Chemokines in OM ; Innate Immunity to Adaptive Immunity in OM: Activation of Lymphocytes ; Part II: Molecular and Cellular Mechanisms Implicated in OM Pathogenesis; In Vivo and In Vitro Models to Study OM Pathogenesis; Animal Models; In Vitro Models; Interactions Between Pathogens and Ear Epithelial Cells; Regulation of Mucin Production and Mucous Cell Metaplasia in OM: Role of Pro-inflammatory Mediators
Epidemiology of Otitis Media: What Have We Learned from the New Century Global Health DisparitiesIntroduction; Global Health Disparities; Conclusion; References; Chapter-3; Impact of Genetic Background in Otitis Media Predisposition; Twin Studies; Linkage Analysis Studies; Candidate Gene Approach; Animal Models; References; Chapter-4; Risk Factors for Recurrent Acute Otitis Media and Chronic Otitis Media with Effusion in Childhood; Host-associated Risk Factors for RAOM; Allergy; Craniofacial Abnormalities; Gastroesophageal Reflux (GER); Adenoids; Genetic Susceptibility
Environmental Risk Factors for RAOMUpper Respiratory Tract Infections (URTI); Day-care Center Attendance; Family Size (Siblings); Passive Smoking; Breast-feeding; Use of Pacifier; References; Chapter-5; Microbiology, Antimicrobial Susceptibility, and Antibiotic Treatment; Introduction; Microbiology; Virus; Viral-Bacterial Interactions; Bacteriology; Polymicrobial Interactions; Implications of Bacterial Vaccine Efforts for Practice ; Bacterial Susceptibility to Antibiotics; Antibiotic Therapy; Initial Antibiotic Treatment Failure; Duration of Therapy; Conclusion; References; Chapter-6
Abnormal Innate and Adaptive Immunity in Otitis MediaAdvances in Potential Bench to Bedside in OM Research; References; Chapter-7; Basic Science Concepts in Otitis Media Pathophysiology and Immunity: Role of Mucins and Inflammation; Part I: The Innate Immunity in Otitis Media; The First Line of Defense of the Innate Immunity: Cellular and Humoral Barriers; The Middle Ear Epithelium; The Mucus in the Middle Ear: An Important Role for Mucins; Antimicrobial Molecules in Effusions; Recognition of Pathogens; The System of the Complement; Receptors of the Innate Immunity
Role of the Inflammation in OMPro-inflammatory Cytokines and Chemokines in OM ; Innate Immunity to Adaptive Immunity in OM: Activation of Lymphocytes ; Part II: Molecular and Cellular Mechanisms Implicated in OM Pathogenesis; In Vivo and In Vitro Models to Study OM Pathogenesis; Animal Models; In Vitro Models; Interactions Between Pathogens and Ear Epithelial Cells; Regulation of Mucin Production and Mucous Cell Metaplasia in OM: Role of Pro-inflammatory Mediators