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000727615 020__ $$a9783319183268$$qelectronic book
000727615 020__ $$a3319183265$$qelectronic book
000727615 020__ $$z9783319183251
000727615 035__ $$aSP(OCoLC)ocn910935383
000727615 035__ $$aSP(OCoLC)910935383
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000727615 24500 $$aLife extension$$h[electronic resource] :$$blessons from drosophila /$$cAlexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova, editors.
000727615 264_1 $$aCham :$$bSpringer,$$c[2015]
000727615 264_4 $$c©2015
000727615 300__ $$a1 online resource (viii, 353 pages) :$$billustrations.
000727615 336__ $$atext$$btxt$$2rdacontent
000727615 337__ $$acomputer$$bc$$2rdamedia
000727615 338__ $$aonline resource$$bcr$$2rdacarrier
000727615 4901_ $$aHealthy ageing and longevity ;$$vv. 3
000727615 504__ $$aIncludes bibliographical references and index.
000727615 5050_ $$aPreface -- SECTION I: Genetic regulation of longevity -- Mutations and quantitative genetic variation: lessons from Drosophila -- Modulation of Drosophila lifespan by neuronal genes -- Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45 -- Superoxide dismutase over-expression and the mitochondrial unfolded protein response -- Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila -- SECTION II: Drosophila models for aging-associated diseases -- Skeletal muscle homeostasis and aging -- Drosophila models of cardiac disease -- Genetic modulation of cardiac functional aging -- Functional links between circadian clocks, redox state and aging in Drosophila -- Drosophila models in therapeutic drug discovery -- SECTION III: Life-extending treatments -- Phytochemicals with lifespan extension effect in Drosophila -- Life extension in Drosophila by inhibitors of histone deacetylases -- Drosophila healthspan extension using dietary manipulation -- The effect of the artificial atmosphere on the flies' longevity -- Effects of several mild stresses applied in adults on aging and longevity -- Life extension via stage-specific drug interventions in Drosophila -- Index.
000727615 506__ $$aAccess limited to authorized users.
000727615 520__ $$aThis book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in biogerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of healthspan, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader. .
000727615 588__ $$aDescription based on online resource; title from PDF title page (viewed June 16, 2015).
000727615 650_0 $$aLife expectancy.
000727615 650_0 $$aLongevity.
000727615 650_0 $$aFruit-flies.
000727615 7001_ $$aVaiserman, Alexander,$$eeditor.
000727615 7001_ $$aMoskalev, Alexey A.,$$eeditor.
000727615 7001_ $$aPasyukova, Elena G.,$$eeditor.
000727615 830_0 $$aHealthy ageing and longevity ;$$vv. 3.
000727615 852__ $$bebk
000727615 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-18326-8$$zOnline Access$$91397441.1
000727615 909CO $$ooai:library.usi.edu:727615$$pGLOBAL_SET
000727615 980__ $$aEBOOK
000727615 980__ $$aBIB
000727615 982__ $$aEbook
000727615 983__ $$aOnline
000727615 994__ $$a92$$bISE