Life extension [electronic resource] : lessons from drosophila / Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova, editors.
Vaiserman, Alexander, editor.; Moskalev, Alexey A., editor.; Pasyukova, Elena G., editor.
2015
QP85
Available Online

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Title
Life extension [electronic resource] : lessons from drosophila / Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova, editors.
ISBN
9783319183268 electronic book
3319183265 electronic book
9783319183251
Published
Cham : Springer, [2015]
Copyright
©2015
Language
English
Description
1 online resource (viii, 353 pages) : illustrations.
Call Number
QP85
Dewey Decimal Classification
612.68
Summary
This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in biogerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of healthspan, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader. .
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from PDF title page (viewed June 16, 2015).
Added Author
Vaiserman, Alexander, editor.
Moskalev, Alexey A., editor.
Pasyukova, Elena G., editor.
Series
Healthy ageing and longevity ; v. 3.
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Preface
SECTION I: Genetic regulation of longevity
Mutations and quantitative genetic variation: lessons from Drosophila
Modulation of Drosophila lifespan by neuronal genes
Life span, stress resistance and age-dependent transcriptome dynamics in fruit flies with constitutive and conditional overexpression of GADD45
Superoxide dismutase over-expression and the mitochondrial unfolded protein response
Effect of Wolbachia infection on aging and longevity-associated genes in Drosophila
SECTION II: Drosophila models for aging-associated diseases
Skeletal muscle homeostasis and aging
Drosophila models of cardiac disease
Genetic modulation of cardiac functional aging
Functional links between circadian clocks, redox state and aging in Drosophila
Drosophila models in therapeutic drug discovery
SECTION III: Life-extending treatments
Phytochemicals with lifespan extension effect in Drosophila
Life extension in Drosophila by inhibitors of histone deacetylases
Drosophila healthspan extension using dietary manipulation
The effect of the artificial atmosphere on the flies' longevity
Effects of several mild stresses applied in adults on aging and longevity
Life extension via stage-specific drug interventions in Drosophila
Index.

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