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000727810 020__ $$a9783319167336$$qelectronic book
000727810 020__ $$a3319167332$$qelectronic book
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000727810 035__ $$aSP(OCoLC)ocn911386367
000727810 035__ $$aSP(OCoLC)911386367
000727810 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dIDEBK$$dGW5XE$$dYDXCP$$dEBLCP$$dAZU
000727810 049__ $$aISEA
000727810 050_4 $$aRC268.48
000727810 08204 $$a616.994071$$223
000727810 24500 $$aMurine models, energy balance, and cancer$$h[electronic resource] /$$cNathan A. Berger, editor.
000727810 264_1 $$aCham :$$bSpringer,$$c[2015]
000727810 264_4 $$c©2015
000727810 300__ $$a1 online resource.
000727810 336__ $$atext$$btxt$$2rdacontent
000727810 337__ $$acomputer$$bc$$2rdamedia
000727810 338__ $$aonline resource$$bcr$$2rdacarrier
000727810 4901_ $$aEnergy balance and cancer,$$x2199-2630 ;$$v10
000727810 504__ $$aIncludes bibliographical references and index.
000727810 5050_ $$aRelevance of Circadian Rhythm in Cancer -- Environmental Manipulation and Neuropeptide Effects on Energy Balance and Cancer -- The MRL Mouse: A Model of Regeneration and Cancer -- Living Large: What Mouse Models Reveal about Growth Hormone and Obesity -- Mouse Models to Study Obesity Effects on Hematologic Malignancies -- Energy Balance, IGF-1 and Cancer: Causal Lessons from Genetically Engineered Mice -- Mouse Models to Study Leptin in Breast Cancer Stem Cells -- Mouse Models used to study the effects of Diabetes, Insulin and IGFs on cancer -- Impact of Energy Balance on Chemically Induced Mammary Carcinogenesis in the Rat -- Models and Mechanisms of High Fat Diet Promotion of Pancreatic Cancer -- Maternal energetics and the developmental origins of prostate cancer in offspring -- Mouse Models to Study the Effect of Natural Products on Obesity Associated -- Mouse Models to Study Metformin Effects in Carcinogenesis.
000727810 506__ $$aAccess limited to authorized users.
000727810 520__ $$aThis volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
000727810 588__ $$aOnline resource; title from PDF title page (viewed June 25, 2015).
000727810 650_0 $$aCancer$$xEtiology$$xResearch.
000727810 650_0 $$aObesity$$xComplications$$xResearch.
000727810 650_0 $$aBioenergetics$$xResearch.
000727810 650_0 $$aTumor markers$$xResearch.
000727810 650_0 $$aMice as laboratory animals.
000727810 7001_ $$aBerger, Nathan A.,$$eeditor.
000727810 830_0 $$aEnergy balance and cancer ;$$vv. 10.
000727810 852__ $$bebk
000727810 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-16733-6$$zOnline Access$$91397441.1
000727810 909CO $$ooai:library.usi.edu:727810$$pGLOBAL_SET
000727810 980__ $$aEBOOK
000727810 980__ $$aBIB
000727810 982__ $$aEbook
000727810 983__ $$aOnline
000727810 994__ $$a92$$bISE