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000727897 019__ $$a914434778
000727897 020__ $$a9783319153445$$qelectronic book
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000727897 08204 $$a615.7$$223
000727897 24500 $$aPreventive and predictive genetics$$h[electronic resource] :$$btowards personalised medicine /$$cGodrey Grech, Iris Grossman, editors
000727897 264_1 $$aCham :$$bSpringer,$$c2015.
000727897 300__ $$a1 online resource.
000727897 336__ $$atext$$btxt$$2rdacontent
000727897 337__ $$acomputer$$bc$$2rdamedia
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000727897 4901_ $$aAdvances in predictive, preventive and personalised medicine,$$x2211-3509 ;$$vvolume 9
000727897 504__ $$aIncludes bibliographical references and index.
000727897 5050_ $$aIntroduction -- Preventive and Predictive Genetics: A perspective -- Roadmap to Drug Development Enabled by Pharmacogenetics -- Preventative and Predictive Genetics: Towards Personalised Medicine -- Pharmacokinetics and Pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of Adverse Drug Reactions -- Pharmacogenomics for haemoglobinopathies therapeutics -- Pharmacogenetics of Neurodegenerative Disorders -- Pharmacogenetics of asthma -- Pharmacogenetics and antineoplastic therapies -- Pharmacogenetics of coumarin anticoagulant therapy -- Implementation of Genomic Medicine: tools and challenges -- Ethical Considerations in the Genomic Era -- Index.
000727897 506__ $$aAccess limited to authorized users.
000727897 520__ $$aTraditionally, medical research comprised of the identification of the pathological causes of a disease, its epidemiology and empirical investigation of treatment response. Intensive genetic research, marked by the completion of the human genome project in 2003, heralded a new era in medical research. While epidemiology and gross pathology are still mainstay useful tools, genetics and genomics have gradually been shown to increase the resolution of drug response research, showing great potential in also informing and identifying the role of genes and their encoded products in the pathophysiology of diseases. This information is already being applied in the prevention of illness, effective early diagnosis, better risk assessment (prognosis), as well as targeted effective and safe treatment allocation (prediction and monitoring). Genetic testing and genomics support personalised medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalised medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.
000727897 588__ $$aOnline resource; title from PDF title page (viewed June 29, 2015).
000727897 650_0 $$aPharmacogenetics.
000727897 650_0 $$aGenetic screening.
000727897 650_0 $$aPersonalized medicine.
000727897 7001_ $$aGrech, Godfrey,$$eeditor.
000727897 7001_ $$aGrossman, Iris,$$eeditor.
000727897 77608 $$iPrint version:$$aGrech, Godfrey$$tPreventive and Predictive Genetics: Towards Personalised Medicine$$dCham : Springer International Publishing,c2015$$z9783319153438
000727897 830_0 $$aAdvances in predictive. preventive and personalised medicine ;$$vv. 9.
000727897 852__ $$bebk
000727897 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-15344-5$$zOnline Access$$91397441.1
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000727897 980__ $$aBIB
000727897 982__ $$aEbook
000727897 983__ $$aOnline
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