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000727904 020__ $$a9783709114025$$qelectronic book
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000727904 050_4 $$aQP601.4$$b.B35 2015eb
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000727904 1001_ $$aBaici, Antonio,$$eauthor.
000727904 24510 $$aKinetics of enzyme-modifier interactions$$h[electronic resource] :$$bselected topics in the theory and diagnosis of inhibition and activation mechanisms /$$cAntonio Baici.
000727904 264_1 $$aWien :$$bSpringer,$$c2015.
000727904 300__ $$a1 online resource :$$billustrations
000727904 336__ $$atext$$btxt$$2rdacontent
000727904 337__ $$acomputer$$bc$$2rdamedia
000727904 338__ $$aonline resource$$bcr$$2rdacarrier
000727904 504__ $$aIncludes bibliographical references and index.
000727904 5050_ $$aBasic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes.- Dichotomous Keys to Enzyme-Modification Mechanisms. .
000727904 506__ $$aAccess limited to authorized users.
000727904 520__ $$aThe kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
000727904 588__ $$aOnline resource; title from PDF title page (viewed June 29, 2015).
000727904 650_0 $$aEnzyme inhibitors.
000727904 650_0 $$aEnzyme activation.
000727904 852__ $$bebk
000727904 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-7091-1402-5$$zOnline Access$$91397441.1
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000727904 983__ $$aOnline
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