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Post-traumatic arthritis [electronic resource] : pathogenesis, diagnosis and management / Steven A. Olson, Farshi Guilak, editors.

Olson, Steven A., editor.; Guilak, Farshid, editor.
2015
RC93.O67
Available Online
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Title
Post-traumatic arthritis [electronic resource] : pathogenesis, diagnosis and management / Steven A. Olson, Farshi Guilak, editors.
ISBN
9781489976062 electronic book
148997606X electronic book
9781489976055
Published
New York : Springer, 2015.
Language
English
Description
1 online resource : illustrations
Call Number
RC93.O67
Dewey Decimal Classification
616.7/223
Summary
Bringing together the most up-to-date research on post-traumatic arthritis (PTA) and its management, this book is a comprehensive presentation of the current thinking on all aspects of the mechanisms of joint injury and subsequent development of PTA. Divided into thematic sections, it includes discussions of the incidence and burden of PTA, both in society at large and in the military population specifically; the relevant experimental work on PTA, from basic science to animal models; peri-articular tissue responses to of joint injury and potential mechanisms of PTA; the current clinical assessment and treatment of common joint injuries leading to PTA; and emerging technologies and treatments for PTA, including biomarkers and stem cell therapies. Taken together, it will be an invaluable resource for orthopedic surgeons, rheumatologists and other joint injury researchers and clinicians.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (viewed July 6, 2015).
Added Author
Olson, Steven A., editor.
Guilak, Farshid, editor.
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Section I: The Problem of Post-Traumatic Arthritis
Arthritis that Develops after Joint Injury: Is it Post-Traumatic Arthritis or Post-Traumatic OsteoArthritis?
Post-Traumatic Arthritis: Definitions and Burden of Disease
Arthritis after Joint Injury: The Military Experience
Section II: Experimental Models of Joint Injury
In Vitro Cartilage Explant Injury Models
Animal Models of Meniscal Injury in Post-Traumatic Arthritis.-Anterior Cruciate Transection/Disruption Models of Posttraumatic Arthritis
Closed Joint ACL Disruption Murine Model of PTA
Whole Joint Models of Articular Injury and Articular Fracture
Instability: Dynamic Loading Models
Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
Section III: Peri-articular Tissue Response to Joint Injury
The Response of Cartilage to Injury
The Response of Subchondral Bone to Injury
Genetic Variability in the Response to Injury
Aging and Post-Traumatic Arthritis.-Potential Mechanisms of PTA: Cell Death
Potential Mechanisms of PTA: Inflammation
Potential Mechanisms of PTA: Oxidative Stress
Potential Mechanisms of PTA: Alterations in Joint Loading
Section IV: Clinical Assessment and Treatment of Patients with Joint Injury
Imaging Specific to Cartilage Injury
Outcomes of ACL Injury: The MOON Consortium
Current Treatment and Outcomes of Intra-articular Fractures
Non-arthroplasty Treatments for PTA in the Lower Extremity
Results of Arthroplasty in Post-Traumatic Arthritis
Section V: Developing and Future Assessment and Therapies
Measurement of Severity of Injury after Articular Fracture and Correlation with Post-Traumatic Arthritis Development
Biomarkers of PTA
Potential Targets for Pharmacologic Therapies for Prevention of PTA.- Stem Cells Therapies for Post-Traumatic Arthritis
Unanswered Questions and Future Directions.

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