Metal response in cupriavidus metallidurans. Volume II, Insights into the structure-function relationship of proteins [electronic resource] / Guy Vandenbussche, Max Mergeay, Rob Van Houdt.
Vandenbussche, Guy, author.; Mergeay, Max, author.; Houdt, Rob Van, author.
2015
QP552.C34 M47 2015eb
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Title Metal response in cupriavidus metallidurans. Volume II, Insights into the structure-function relationship of proteins [electronic resource] / Guy Vandenbussche, Max Mergeay, Rob Van Houdt.
Author Vandenbussche, Guy, author.
ISBN 9783319206240 electronic book
3319206249 electronic book
9783319206233
Published Cham : Springer, 2015.
Language English
Description 1 online resource (vii, 70 pages) : illustrations.
Call Number QP552.C34 M47 2015eb
Dewey Decimal Classification 572/.696
Summary This book is the second volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this second volume, the structural and catalytic data from bacterial primary and secondary transporters (P-ATPases, tripartite chemiosmotic cation/proton efflux systems, cation diffusion facilitators, Major Facilitator Superfamily and some minor categories) are outlined and detailed for the corresponding C. metallidurans proteins. The available three-dimensional structures are reviewed in detail, including RND and membrane fusion proteins (from tripartite chemiosmotic cation/proton efflux systems), sigma and anti-sigma regulatory proteins of the cnr efflux system (resistance to cobalt and nickel) and various periplasmic proteins mainly involved in the response to copper and mercury. In addition, the first volume sketches the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, to illustrate the interactions between bacteria and human activities and the possible evolutionary consequences on bacterial genomes especially as far as the association of metal resistance genes with mobile genetic elements is concerned. It provides a detailed description of the response and underlying genetic determinants of type strain Cupriavidus metallidurans CH34 to a variety of metals. With high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification carried by its megaplasmids pMOL28 and pMOL30. This description is complemented with the genomic context of the metal response genes in C. metallidurans CH34 with a focus on its mobilome including insertion sequence elements, transposons, integrative and conjugative elements and genomic islands.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed July 9, 2015).
Added Author Mergeay, Max, author.
Houdt, Rob Van, author.
Series SpringerBriefs in molecular science. Biometals.
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Introduction
Bacterial cation transporters and their representatives in Cupriavidus metallidurans
Primary active transport
Secondary active transport
Structural efforts on C. metallidurans CH34 proteins involved in the response to meta lions
HME-RND-driven systems
Small periplasmic proteins
Regulatory proteins
Concluding remarks
References.

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