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000728049 020__ $$a9783662473719$$qelectronic book
000728049 020__ $$a3662473712$$qelectronic book
000728049 020__ $$z9783662473702
000728049 0247_ $$a10.1007/978-3-662-47371-9$$2doi
000728049 035__ $$aSP(OCoLC)ocn913468916
000728049 035__ $$aSP(OCoLC)913468916
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000728049 049__ $$aISEA
000728049 050_4 $$aQP88.5$$b.M67 2015eb
000728049 08204 $$a612.7/9015118$$223
000728049 1001_ $$aMoss, Gary P.,$$eauthor.
000728049 24510 $$aPredictive methods in percutaneous absorption$$h[electronic resource] /$$cGary P. Moss, Darren R. Gullick, Simon C. Wilkinson.
000728049 264_1 $$aHeidelberg :$$bSpringer,$$c2015.
000728049 300__ $$a1 online resource (xv, 199 pages) :$$billustrations.
000728049 336__ $$atext$$btxt$$2rdacontent
000728049 337__ $$acomputer$$bc$$2rdamedia
000728049 338__ $$aonline resource$$bcr$$2rdacarrier
000728049 504__ $$aIncludes bibliographical references and index.
000728049 506__ $$aAccess limited to authorized users.
000728049 520__ $$aThis book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
000728049 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed July 8, 2015).
000728049 650_0 $$aSkin absorption$$xMathematical models.
000728049 650_0 $$aSkin absorption$$xComputer simulation.
000728049 7001_ $$aGullick, Darren R.$$eauthor.
000728049 7001_ $$aWilkinson, Simon C.$$eauthor.
000728049 852__ $$bebk
000728049 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-662-47371-9$$zOnline Access$$91397441.1
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000728049 980__ $$aEBOOK
000728049 980__ $$aBIB
000728049 982__ $$aEbook
000728049 983__ $$aOnline
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