Chemistry, biochemistry and pharmacology of hydrogen sulfide [electronic resource] / edited by Philip K. Moore, Matt Whiteman.
Moore, P. K. (Philip Keith), 1954- editor.; Whiteman, Matt, editor.
2015
RA1247.H8
Available Online

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Title
Chemistry, biochemistry and pharmacology of hydrogen sulfide [electronic resource] / edited by Philip K. Moore, Matt Whiteman.
ISBN
9783319181448 electronic book
3319181440 electronic book
9783319181431
3319181432
DOI
https://doi.org/10.1007/978-3-319-18144-8
Published
Cham : Springer, 2015.
Language
English
Description
1 online resource (vi, 395 pages) : illustrations.
Item Number
10.1007/978-3-319-18144-8 doi
Call Number
RA1247.H8
Dewey Decimal Classification
615.9/1
Summary
This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.
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Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Moore, P. K. (Philip Keith), 1954- editor.
Whiteman, Matt, editor.
Series
Handbook of experimental pharmacology ; 230.
Available in Other Form
Chemistry
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Part I Biochemistry, molecular biology and chemistry
1 H2Ssynthesizing enzymes: biochemistry and molecular aspects
Part II Molecular mechanisms of action
2 Sulfhydration and H2S
3 Persulfide formation and H2S
Part III Cardiovascular system
4 H2S and blood vessels
an overview
5 Hydrogen sulfide and urogenital tract
6 H2S
cardiac function and cardiac disease
7 H2S and platelets
a possible role in thrombosis?
Part IV Inflammation and inflammatory disease
8 H2S and inflammation
an overview
9 H2S and neuroinflammation
Part V H2S and the nervous system
10 Brain, learning and memory: role in neurodegenerative diseases
11 H2S and pain
inflammatory and neuropathic
Part VI H2S, angiogenesis and cancer
12 H2S and colon cancer
13 The role of H2S in cancer and tumor development
Part VII H2S and ageing
14 H2S
a new approach to lifespan enhancement and healthy aging?
Part VIII H2S, measurement and possible therapeutics?
15 Measurement of H2S
probes comes of age?
16 S-propargylcysteine
a novel H2S donor with therapeutic potential
17 Mitochondria-targetted sulfide donors
18 Medicinal chemistry
insights into the development of novel H2S donors.

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