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000728222 020__ $$a9783319188812$$qelectronic book
000728222 020__ $$a331918881X$$qelectronic book
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000728222 24504 $$aThe male role in pregnancy loss and embryo implantation failure$$h[electronic resource] /$$cRichard Bronson, editor.
000728222 264_1 $$aCham :$$bSpringer,$$c2015.
000728222 264_4 $$c©2015
000728222 300__ $$a1 online resource.
000728222 336__ $$atext$$btxt$$2rdacontent
000728222 337__ $$acomputer$$bc$$2rdamedia
000728222 338__ $$aonline resource$$bcr$$2rdacarrier
000728222 4901_ $$aAdvances in experimental medicine and biology,$$vvolume 868
000728222 504__ $$aIncludes bibliographical references.
000728222 5050_ $$aPreface -- Meiotic Non-disjunction -- Insights into the Origin and Significance of Aneuploidy in Human Spermatozoa -- Damage to Sperm DNA Mediated by Reactive Oxygen Species: Its Impact on Human Reproduction and the Health Trajectory of Offspring -- Small RNAs: Their Possible Roles in Reproductive Failure -- The Sperm Epigenome, Male Aging and Potential Effects on the Embryo -- The Role of Uterine NK Cells in Normal Reproduction and Reproductive Disorders -- Seminal fluid Signaling in the Female Reproductive Tract: Implications for Reproductive Success and Offspring Health -- Role of Seminal Plasma in Human Female Reproductive Failure: Immunomodulation, Inflammation and Infections -- Human Leukocyte Antigen-G Within the Male Reproductive System -- Implications for Reproduction -- Prostasomes -- Their Characterization: Implications for Human Reproduction -- The Paternal Contribution to Fetal Tolerance -- Index.
000728222 506__ $$aAccess limited to authorized users.
000728222 520__ $$aNovel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.
000728222 588__ $$aOnline resource; title from PDF title page (viewed July 21, 2015).
000728222 650_0 $$aSpermatozoa$$xMotility$$xDisorders.
000728222 650_0 $$aHuman embryo$$xTransplantation.
000728222 650_0 $$aHuman reproduction$$xImmunological aspects.
000728222 7001_ $$aBronson, Richard,$$d1941-$$eeditor.
000728222 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 868.
000728222 852__ $$bebk
000728222 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-18881-2$$zOnline Access$$91397441.1
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