000728257 000__ 03126cam\a2200397Ii\4500
000728257 001__ 728257
000728257 005__ 20230306141002.0
000728257 006__ m\\\\\o\\d\\\\\\\\
000728257 007__ cr\cn\nnnunnun
000728257 008__ 150721s2015\\\\sz\a\\\\o\\\\\000\0\eng\d
000728257 020__ $$a9783319200989$$qelectronic book
000728257 020__ $$a3319200984$$qelectronic book
000728257 020__ $$z9783319200972
000728257 035__ $$aSP(OCoLC)ocn914229853
000728257 035__ $$aSP(OCoLC)914229853
000728257 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dGW5XE$$dN$T$$dIDEBK$$dAZU$$dYDXCP
000728257 049__ $$aISEA
000728257 050_4 $$aQP606.P78
000728257 08204 $$a572.6$$223
000728257 24500 $$aSH domains$$h[electronic resource] :$$bstructure, mechanisms and applications /$$cNatalya Kurochkina, editor.
000728257 264_1 $$aCham :$$bSpringer,$$c2015.
000728257 300__ $$a1 online resource (viii, 253 pages) :$$bcolor illustrations
000728257 336__ $$atext$$btxt$$2rdacontent
000728257 337__ $$acomputer$$bc$$2rdamedia
000728257 338__ $$aonline resource$$bcr$$2rdacarrier
000728257 5050_ $$aSH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domains' Interaction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains.
000728257 506__ $$aAccess limited to authorized users.
000728257 520__ $$aThis book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
000728257 588__ $$aOnline resource; title from PDF title page (viewed July 23, 2015)
000728257 650_0 $$aProtein-tyrosine kinase.
000728257 650_0 $$aAmino acids.
000728257 7001_ $$aKurochkina, Natalya,$$eeditor.
000728257 852__ $$bebk
000728257 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-20098-9$$zOnline Access$$91397441.1
000728257 909CO $$ooai:library.usi.edu:728257$$pGLOBAL_SET
000728257 980__ $$aEBOOK
000728257 980__ $$aBIB
000728257 982__ $$aEbook
000728257 983__ $$aOnline
000728257 994__ $$a92$$bISE