@article{733524,
      recid = {733524},
      author = {Miller, Daniel L., and Stack, M. Sharon,},
      title = {Human papillomavirus (HPV)-associated oropharyngeal cancer  / [electronic resource]},
      pages = {1 online resource (viii, 314 pages) :},
      note = {Includes index.},
      abstract = {Head and neck squamous cell carcinoma (HNSCC), the sixth  most prevalent cancer worldwide, remains a very difficult  disease to treat and cure despite intensive investigation  into molecular etiologies and tumor progression pathways.  Due to public health efforts encouraging smoking cessation,  the overall incidence of HNSCC has decreased in recent  years in many countries. ℗ℓIn contrast, the incidence of  oropharyngeal squamous cell carcinoma (OPSCC) has increased  significantly, and this subtype of HNSCC is commonly  associated with human papillomavirus (HPV) infection.℗ℓ  Moreover, individuals with HPV-positive OPSCC are generally  younger and are frequently non-smokers, suggesting that  HPV-associated OPSCC represents a distinct biologic entity.  ℗ℓ This volume summarizes the spectrum of current  HPV-associated OPSCC research from the fundamental basic  science to translational surgery and treatment approaches.  Chapters are contributed by authoritative leaders in the  fields of research and clinical care. Initial chapters  address epidemiology, behavioral correlates of HPV  infection, and racial disparities in oropharyngeal cancer.  This is followed by chapters detailing HPV virology with  focus on viral transformation, viral replication, and host  response to viral infection. The molecular biology of  HPV-associated OPSCC is investigated in chapters detailing  alterations in signaling networks and unique mutational  profiles of human tumors. Clinical presentation, surgical  perspectives, and treatment paradigms specific to  HPV-associated OPSCC conclude the volume.℗ℓ This  comprehensive volume provides an up-to-date overview of  both scientific discovery and clinical management of this  emerging public health problem.},
      url = {http://library.usi.edu/record/733524},
      doi = {https://doi.org/10.1007/978-3-319-21100-8},
}