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000733555 020__ $$a9783319194974$$qelectronic book
000733555 020__ $$a3319194976$$qelectronic book
000733555 020__ $$z9783319194967
000733555 0247_ $$a10.1007/978-3-319-19497-4$$2doi
000733555 035__ $$aSP(OCoLC)ocn917153116
000733555 035__ $$aSP(OCoLC)917153116
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000733555 049__ $$aISEA
000733555 050_4 $$aQH671
000733555 08204 $$a571.9/36$$223
000733555 24500 $$aProteases in apoptosis$$h[electronic resource] :$$bpathways, protocols and translational advances /$$cKakoli Bose, editor.
000733555 264_1 $$aCham :$$bSpringer,$$c2015.
000733555 300__ $$a1 online resource (xv, 245 pages) :$$billustrations.
000733555 336__ $$atext$$btxt$$2rdacontent
000733555 337__ $$acomputer$$bc$$2rdamedia
000733555 338__ $$aonline resource$$bcr$$2rdacarrier
000733555 500__ $$aIncludes index.
000733555 5050_ $$aApoptosis: Pathways, Molecules and Beyond -- Caspases -- key players in apoptosis -- Calpains and Granzymes: non-caspase proteases in cell death -- Cathepsins and HtrAs -- multitasking proteases in programmed cell death -- Proteases in Apoptosis: Protocols and Methods -- Preclinical Animal Model and Non-invasive Imaging in Apoptosis.
000733555 506__ $$aAccess limited to authorized users.
000733555 520__ $$aThis book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics℗ℓare recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.
000733555 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed August 12, 2015).
000733555 650_0 $$aApoptosis.
000733555 650_0 $$aProteolytic enzymes.
000733555 7001_ $$aBose, Kakoli,$$eeditor.
000733555 77608 $$iPrint version:$$z9783319194967
000733555 85280 $$bebk$$hSpringerLink
000733555 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-19497-4$$zOnline Access$$91397441.1
000733555 909CO $$ooai:library.usi.edu:733555$$pGLOBAL_SET
000733555 980__ $$aEBOOK
000733555 980__ $$aBIB
000733555 982__ $$aEbook
000733555 983__ $$aOnline
000733555 994__ $$a92$$bISE