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000733629 019__ $$a918969594
000733629 020__ $$a9783319087177$$qelectronic book
000733629 020__ $$a3319087177$$qelectronic book
000733629 020__ $$z9783319087160
000733629 0247_ $$a10.1007/978-3-319-08717-7$$2doi
000733629 035__ $$aSP(OCoLC)ocn918841138
000733629 035__ $$aSP(OCoLC)918841138$$z(OCoLC)918969594
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000733629 049__ $$aISEA
000733629 050_4 $$aQP551
000733629 08204 $$a572$$223
000733629 24500 $$aADAMTS13$$h[electronic resource] :$$bbiology and disease /$$cGeorge M. Rodgers, editor.
000733629 264_1 $$aCham :$$bSpringer,$$c2015.
000733629 264_4 $$c©2015
000733629 300__ $$a1 online resource.
000733629 336__ $$atext$$btxt$$2rdacontent
000733629 337__ $$acomputer$$bc$$2rdamedia
000733629 338__ $$aonline resource$$bcr$$2rdacarrier
000733629 504__ $$aIncludes bibliographical references and index.
000733629 5050_ $$a1. A13: Structure and function -- 2. A13: The von Willebrand factor cleaving protease -- 3. A13: Angiogenesis and other biologic activities -- 4. A13: Assays -- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome) -- 6. Acquired A13 deficiency (TTP) -- 7. Related thrombotic microangiopathies -- 8. Future directions.
000733629 506__ $$aAccess limited to authorized users.
000733629 520__ $$aThis comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. ℗ℓ Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
000733629 588__ $$aOnline resource; title from PDF title page (viewed August 18, 2015).
000733629 650_0 $$aBiochemistry.
000733629 650_0 $$aCytology.
000733629 650_0 $$aThrombotic thrombocytopenic purpura.
000733629 650_0 $$aProteomics.
000733629 650_0 $$aProteolytic enzymes.
000733629 7001_ $$aRodgers, George M.,$$eeditor.
000733629 77608 $$iPrint version:$$z9783319087160
000733629 852__ $$bebk
000733629 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-08717-7$$zOnline Access$$91397441.1
000733629 909CO $$ooai:library.usi.edu:733629$$pGLOBAL_SET
000733629 980__ $$aEBOOK
000733629 980__ $$aBIB
000733629 982__ $$aEbook
000733629 983__ $$aOnline
000733629 994__ $$a92$$bISE