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Molecular oncology testing for solid tumors [electronic resource] : a pragmatic approach / Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett, editors.

Idowu, Michael Ola, editor.; Dumur, Catherine Isabelle, editor.; Garrett, Carleton T., editor.
2015
RC270
Available Online
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Title
Molecular oncology testing for solid tumors [electronic resource] : a pragmatic approach / Michael Ola Idowu, Catherine Isabelle Dumur, Carleton Theodore Garrett, editors.
ISBN
9783319163048 electronic book
3319163043 electronic book
9783319163031
3319163035 (print)
9783319163031 (print)
DOI
https://doi.org/10.1007/978-3-319-16304-8
Published
Cham : Springer, 2015.
Language
English
Description
1 online resource (ix, 742 pages) : illustrations.
Item Number
10.1007/978-3-319-16304-8 doi
Call Number
RC270
Dewey Decimal Classification
616.99/4075
Summary
This text is designed to present an up-to-date practical approach to molecular testing in an easy to understand format. Emphasis is placed on molecular testing for solid tumors, while underscoring the following: i) the crucial role of pathologists in ensuring specimen adequacy for molecular testing; ii) current molecular assays/platforms (including next-generation sequencing); iii) clinical utility and limitations of biomarkers to enable effective communication with clinicians; iv) the importance of quality assurance metrics to ensure accurate and reproducible results; v) pitfalls in test interpretation (that may lead to False Positive or False Negative interpretations); vi) importance of using standard nomenclature, including exercises on variant (mutation) description; vii) regulatory affairs, coding and reimbursement. The uniqueness of this text is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. Molecular Oncology Testing for Solid Tumors will enable readers to easily understand the Ordering, Processing, Interpretation, Reporting and the clinical Application (OPIRA) process of molecular testing or biomarkers.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed August 24, 2015).
Added Author
Idowu, Michael Ola, editor.
Dumur, Catherine Isabelle, editor.
Garrett, Carleton T., editor.
Available in Other Form
Print version: 9783319163031
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Part I. Overview of Basic Cellular Biology
1. Normal molecular biology and definition of terms
2. Pathologic changes: Chromosomes, genes, DNA, RNA and proteins
3. Standard nomenclature
introduction and brief overview
Part II. Molecular Oncology Methodology
4. General principles of Oncology testing
5. Molecular methodologies
6. General principles of validating a molecular test
Part III. Molecular testing in Solid Tumors
7. Lung and mediastinum
8. Breast
9. Head and neck (salivary glands)
10. Thyroid and parathyroid (endocrine)
11. Gastrointestinal and Pancreatobiliary
12. Soft tissue
13. Genitourinary system
14. Central Nervous System
15. Skin and adnexa
16. Common Hereditary Cancer Syndromes
Part IV. The future is here
17. Application of next generation sequencing
Part V. Quality Assurance and Regulatory affairs
18. Quality Assurance
pre-analytic, analytic and post-analytic
19. Regulatory affairs (including accreditation)
20. Coding and re-imbursement.

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