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000733696 020__ $$a9783319187297$$qelectronic book
000733696 020__ $$a3319187295$$qelectronic book
000733696 020__ $$z9783319187280
000733696 0247_ $$a10.1007/978-3-319-18729-7$$2doi
000733696 035__ $$aSP(OCoLC)ocn919002284
000733696 035__ $$aSP(OCoLC)919002284
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000733696 050_4 $$aQH603.C43$$bM34 2015eb
000733696 08204 $$a572/.696$$223
000733696 24500 $$aNuclear receptors$$h[electronic resource] :$$bfrom structure to the clinic /$$cIain J. McEwan, Raj Kumar, editors.
000733696 264_1 $$aCham :$$bSpringer,$$c2015.
000733696 300__ $$a1 online resource.
000733696 336__ $$atext$$btxt$$2rdacontent
000733696 337__ $$acomputer$$bc$$2rdamedia
000733696 338__ $$aonline resource$$bcr$$2rdacarrier
000733696 504__ $$aIncludes bibliographical references and index.
000733696 5050_ $$a1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic -- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors -- 3. Glucocorticoid Receptor Structure and Function -- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? -- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors -- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor -- 7. Structural Analysis of Heterodimeric Nuclear Receptors -- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS -- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) -- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes -- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors -- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).
000733696 506__ $$aAccess limited to authorized users.
000733696 520__ $$aNuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
000733696 650_0 $$aNuclear receptors (Biochemistry)
000733696 650_0 $$aHuman genome.
000733696 7001_ $$aMcEwan, I. J.,$$eeditor.
000733696 7001_ $$aKumar, Raj,$$eeditor.
000733696 77608 $$iPrint version:$$z9783319187280
000733696 852__ $$bebk
000733696 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-18729-7$$zOnline Access$$91397441.1
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000733696 980__ $$aEBOOK
000733696 980__ $$aBIB
000733696 982__ $$aEbook
000733696 983__ $$aOnline
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