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000737567 019__ $$a930836590$$a931593271$$a932168777
000737567 020__ $$a9783319246635$$qelectronic book
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000737567 0247_ $$a10.1007/978-3-319-24663-5$$2doi
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000737567 08204 $$a616.079$$223
000737567 1001_ $$aRibatti, Domenico,$$d1956-$$eauthor.
000737567 24514 $$aThe development of immunologic competence$$h[electronic resource] /$$cDomenico Ribatti.
000737567 264_1 $$aCham :$$bSpringer International Publishing,$$c[2015]
000737567 264_4 $$c©2015
000737567 300__ $$a1 online resource (viii, 60 pages) :$$bcolor illustrations, photographs
000737567 336__ $$atext$$btxt$$2rdacontent
000737567 337__ $$acomputer$$bc$$2rdamedia
000737567 338__ $$aonline resource$$bcr$$2rdacarrier
000737567 347__ $$atext file$$bPDF$$2rda
000737567 504__ $$aIncludes bibliographical references (pages 47-57) and index.
000737567 5050_ $$aPreface.- Introduction.- Human hematopoietic development.-The Bursa of Fabricius.- The Thymus.- Clinical correlates -- References -- Index. .
000737567 506__ $$aAccess limited to authorized users.
000737567 520__ $$aThis book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.
000737567 588__ $$aOnline resource; title from PDF title page (viewed December 15, 2015).
000737567 650_0 $$aImmune system.
000737567 650_0 $$aThymus.
000737567 650_0 $$aAutoimmune diseases.
000737567 650_0 $$aImmunodeficiency.
000737567 77608 $$iPrint version:$$aRibatti, Domenico$$tThe Development of Immunologic Competence$$dCham : Springer International Publishing,c2015$$z9783319246611
000737567 85280 $$bebk$$hSpringerLink
000737567 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-24663-5$$zOnline Access$$91397441.1
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000737567 980__ $$aEBOOK
000737567 980__ $$aBIB
000737567 982__ $$aEbook
000737567 983__ $$aOnline
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