000737591 000__ 03986cam\a2200541Ii\4500 000737591 001__ 737591 000737591 005__ 20230306141049.0 000737591 006__ m\\\\\o\\d\\\\\\\\ 000737591 007__ cr\cn\nnnunnun 000737591 008__ 151201s2015\\\\sz\\\\\\o\\\\\001\0\eng\d 000737591 019__ $$a931593283$$a932333752 000737591 020__ $$a9783319211671$$qelectronic book 000737591 020__ $$a3319211676$$qelectronic book 000737591 020__ $$z9783319211664 000737591 0247_ $$a10.1007/978-3-319-21167-1$$2doi 000737591 035__ $$aSP(OCoLC)ocn930703384 000737591 035__ $$aSP(OCoLC)930703384$$z(OCoLC)931593283$$z(OCoLC)932333752 000737591 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dIDEBK$$dYDXCP$$dEBLCP$$dNUI$$dOCLCO$$dN$T$$dCDX 000737591 049__ $$aISEA 000737591 050_4 $$aRC261-271 000737591 08204 $$a610 000737591 1001_ $$aAscierto, Paolo A. 000737591 24510 $$aDevelopments in T cell based cancer immunotherapies.$$h[electronic resource] /$$cPaolo A. Ascierto, David F. Stroncek, Ena Wang, editors. 000737591 264_1 $$aCham :$$bHumana Press,$$c2015. 000737591 300__ $$a1 online resource. 000737591 336__ $$atext$$btxt$$2rdacontent 000737591 337__ $$acomputer$$bc$$2rdamedia 000737591 338__ $$aonline resource$$bcr$$2rdacarrier 000737591 4901_ $$aCancer Drug Discovery and Development 000737591 500__ $$aIncludes index. 000737591 5050_ $$a1 New insight of peptide vaccination in cancer immunotherapy -- 2 The determinants of T cell function for effective anticancer vaccine -- 3 T cell fate in the tumor microenvironment -- 4 T cell receptor avidity and affinity and tumor specific TCR engineer -- 5 Host genetic variation and somatic alteration associated with favorable or compromised T cell function -- 6 Production of Clinical T Cell Therapies -- 7 Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes.-8 Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer -- 9 T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy -- 10 T cell modulation- anti-OD-1 antibodies for the treatment of cancer -- 11 T cell based therapies in combination with other procedures -- 12 Chimeric antigen receptor T cells CD19 CAR -- 13 Hematopoietic Stem Cell transplantation as immune therapy of malignancies. 000737591 506__ $$aAccess limited to authorized users. 000737591 520__ $$aThis volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed. 000737591 650_0 $$aCancer$$xImmunotherapy. 000737591 650_0 $$aMedicine. 000737591 650_0 $$aCancer$$xResearch. 000737591 650_0 $$aImmunology. 000737591 650_0 $$aMolecular biology. 000737591 650_0 $$aCytology. 000737591 7001_ $$aAscierto, Paolo A.,$$eeditor. 000737591 7001_ $$aStroncek, David F.,$$eeditor. 000737591 7001_ $$aWang, Ena,$$eeditor. 000737591 77608 $$iPrint version:$$aAscierto, Paolo A.$$tDevelopments in T Cell Based Cancer Immunotherapies$$dCham : Springer International Publishing,c2015$$z9783319211664 000737591 830_0 $$aCancer drug discovery and development. 000737591 85280 $$bebk$$hSpringerLink 000737591 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-21167-1$$zOnline Access$$91397441.1 000737591 909CO $$ooai:library.usi.edu:737591$$pGLOBAL_SET 000737591 980__ $$aEBOOK 000737591 980__ $$aBIB 000737591 982__ $$aEbook 000737591 983__ $$aOnline 000737591 994__ $$a92$$bISE