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Foreword; Contents; Contributors; Chapter 1: microRNAs in the Malignant Transformation Process; Introduction; Colorectal Cancer; Pancreatic Cancer; Malignant Peripheral Nerve Sheath Tumor; Prostate Cancer; Conclusion; References; Chapter 2: microRNA and Chronic Lymphocytic Leukemia; Chronic Lymphocytic Leukemia Before miRNAs Revolution; What Are miRNAs?; microRNA Signature in Chronic Lymphocytic Leukemia; miRNA's Mechanism of Action in CLL; miRNAs in CLL Mouse Models; miRNAs as Diagnostic and Prognostic Factors for CLL; miRNAs and RNA-Inhibition Therapy in CLL; Conclusions
MicroRNA Deregulation in GISTMicroRNAs Associated with Clinical and Pathological Features in GIST; MicroRNAs Associated with Chromosomal and Genetic Alterations in GIST; MicroRNAs in Imatinib Resistance in GIST; Clinical Implications of microRNAs in GIST; Conclusion; References; Chapter 5: Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy; Introduction; Pancreatic Cancer: A Major Clinical Problem; Deregulation of miRNAs in Pancreatic Cancer; Role of miRNAs in Pancreatic Cancer
MiRNAs in Pancreatic Cancer Initiation and Promotion miRNAs in Pancreatic Cancer Metastasis; miRNAs in Chemoresistance of Pancreatic Cancer; Opportunities for the Clinical Use of miRNAs in Pancreatic Cancer Management; miRNAs as Diagnostic Markers; miRNAs in Prognostic Assessment; miRNAs as Therapeutic Targets; Conclusion and Future Perspectives; References; Chapter 6: microRNAs and Colorectal Cancer; Introduction; MiRNAs and Their Relationship to the Hallmarks of Cancer; Regulation of Cell Proliferation and Evasion of Growth Suppressors; Evasion of Apoptosis
Regulating Immortalization or Senescence Induction of Angiogenesis; Migration Invasion and Metastasis; Promotion of Genomic Instability; Reprogramming of Energy Metabolism; Evasion of Immune System and Inflammation; Clinical Implications of miRNAs in Colorectal Cancer; MiRNAs as Diagnostics; Circulating miRNAs; Mucosal Colon Wash Fluid; Feces; microRNAs as Therapeutics; References; Chapter 7: microRNAs and Prostate Cancer; Introduction; Role of miRNA in the Epigenetic Reprogramming of Prostate Cancer Metastasis; Epigenetic Silencing by EZH2 Regulate miRNA
MicroRNA Deregulation in GISTMicroRNAs Associated with Clinical and Pathological Features in GIST; MicroRNAs Associated with Chromosomal and Genetic Alterations in GIST; MicroRNAs in Imatinib Resistance in GIST; Clinical Implications of microRNAs in GIST; Conclusion; References; Chapter 5: Insights into the Role of microRNAs in Pancreatic Cancer Pathogenesis: Potential for Diagnosis, Prognosis, and Therapy; Introduction; Pancreatic Cancer: A Major Clinical Problem; Deregulation of miRNAs in Pancreatic Cancer; Role of miRNAs in Pancreatic Cancer
MiRNAs in Pancreatic Cancer Initiation and Promotion miRNAs in Pancreatic Cancer Metastasis; miRNAs in Chemoresistance of Pancreatic Cancer; Opportunities for the Clinical Use of miRNAs in Pancreatic Cancer Management; miRNAs as Diagnostic Markers; miRNAs in Prognostic Assessment; miRNAs as Therapeutic Targets; Conclusion and Future Perspectives; References; Chapter 6: microRNAs and Colorectal Cancer; Introduction; MiRNAs and Their Relationship to the Hallmarks of Cancer; Regulation of Cell Proliferation and Evasion of Growth Suppressors; Evasion of Apoptosis
Regulating Immortalization or Senescence Induction of Angiogenesis; Migration Invasion and Metastasis; Promotion of Genomic Instability; Reprogramming of Energy Metabolism; Evasion of Immune System and Inflammation; Clinical Implications of miRNAs in Colorectal Cancer; MiRNAs as Diagnostics; Circulating miRNAs; Mucosal Colon Wash Fluid; Feces; microRNAs as Therapeutics; References; Chapter 7: microRNAs and Prostate Cancer; Introduction; Role of miRNA in the Epigenetic Reprogramming of Prostate Cancer Metastasis; Epigenetic Silencing by EZH2 Regulate miRNA