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Part I. The rationale for translational informatics. 1. An introduction to translational informatics and the future of knowledge-driven healthcare
2. A prototype of translational informatics in action
Part II. Foundations of translational informatics. 3. Personalized medicine
4. Leveraging electronic health records for phenotyping
5. Mining the bibliome
Part III. Applications of translational informatics. 6. Driving clinical and translational research using biomedical informatics
7. Using big data
8. In silico hypothesis discovery
9. Patient engagement and consumerism
Part IV. The future of translational informatics and knowledge-driven healthcare. 10. Future directions for translational informatics.

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