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000746112 020__ $$a9781493924042$$qelectronic book
000746112 020__ $$a1493924044$$qelectronic book
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000746112 0247_ $$a10.1007/978-1-4939-2404-2$$2doi
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000746112 24500 $$aLongevity genes$$h[electronic resource] :$$ba blueprint for aging /$$cGil Atzmon, PhD editor.
000746112 264_1 $$aNew York :$$bSpringer,$$c[2015]
000746112 264_4 $$c©2015
000746112 300__ $$a1 online resource :$$billustrations.
000746112 336__ $$atext$$btxt$$2rdacontent
000746112 337__ $$acomputer$$bc$$2rdamedia
000746112 338__ $$aonline resource$$bcr$$2rdacarrier
000746112 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 847
000746112 504__ $$aIncludes bibliographical references and index..
000746112 5050_ $$aEvolutionary Genetic Bases of Longevity and Senescence -- Candidate Genes That Affect Aging Through Protein Homeostasis -- Autophagy and Aging -- A Genetic View of the Mitochondrial Role in Aging: Killing Us Softly -- GWAS and Meta-analysis in Aging/Longevity -- Exome and Whole Genome Sequencing in Aging and Longevity -- Models to Explore Genetics of Human Aging -- Systems Biology of Aging -- Epigenetics of Aging.
000746112 506__ $$aAccess limited to authorized users.
000746112 520__ $$aThe release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.
000746112 588__ $$aVendor-supplied metadata.
000746112 650_0 $$aLongevity$$xGenetic aspects.
000746112 650_0 $$aAging.
000746112 7001_ $$aAtzmon, Gil,$$eeditor.
000746112 77608 $$iPrint version:$$z9781493924035
000746112 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 847.
000746112 85280 $$bebk$$hSpringerLink
000746112 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-2404-2$$zOnline Access$$91397441.1
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