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Preface; Abbreviations; Contents; Introduction; The Structure and Function of Apolipoprotein Mimetic Peptides; Bibliography; The Editors; HDL and the Amphipathic Helix; Discovery, Isolation, and Characterization of HDL; Early History of HDL Structure; Discovery of the Amphipathic Helix: An Untold Story; The Amphipathic Helix and HDL; Current History of HDL Structure; Current Thoughts on the Biomedical Implications of HDL; What Are Peptide Mimetics and Should I Care?; References; ApoA-I Mimetic Peptides: A Review of the Present Status
ApoA-I Mimetic Peptides Were Designed to Mimic a Plasma Apolipoprotein The Peptides Were Effective in a Large Number of Animal Models of Disease; The 4F Peptide Was Tested in Human Clinical Trials; Reconciling the Divergent Results from the Clinical Trials; Overcoming the Barrier of the High Cost of Production of Chemically Synthesized ApoA-I Mimetic Peptides; Determining the Mechanism of Action of Oral ApoA-I Mimetic Peptides; Other Peptides; Conclusions; References; Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux; Introduction; Reverse Cholesterol Transport Pathway
Apolipoprotein Mimetic PeptidesESP24218 Peptide; D-4F Peptide; L-4F Peptide; Retroinverso Peptides; 5A Peptide; ATI-5261 Peptide; Summary; References; ApoA-I Mimetic Peptides and Diabetes; Introduction; 4F Background; 4F and Diabetes; Conclusion; References; Apolipoprotein A-I Mimetic Peptides in Mouse Models of Cancer; Introduction; Inflammation and Lipoproteins in Cancer; ApoA-I and Ovarian Cancer; ApoA-I Mimetic Peptides as Cancer Therapeutics; ApoA-I Mimetic Peptides and Colon Cancer; Conclusions; References
Effects of ApoA-I Mimetic Peptide L-4F in LPS-Mediated InflammationIntroduction; LPS and Sepsis; HDL and LPS; ApoA-I and Sepsis; ApoA-I Mimetic Peptides 18A and 4F; ApoA-I Mimetic Peptide L-4F and LPS; ApoA-I Mimetic Peptide L-4F in Polymicrobial Septic Models; Efficacy of L-4F in Different Models of Atherosclerosis and Metabolic Syndrome (Diabetes) Could Be in Part Accounted for by Its Anti-endotoxin Property; References; Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation; Introduction; Genetic Deletion of ApoA-I; 4F Inhibits Airway Inflammation
Potential Mechanisms of Action Other Apolipoprotein Mimetics That Modulate Airway Inflammation; Novel Apolipoprotein Mimetics; References; Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides; Introduction; Macrophage Polarization; Macrophage Heterogeneity and Atherosclerosis; HDL Composition and Function; Dysfunctional HDL; HDL-Associated S1P and Macrophage Phenotype; ABCA1 and Macrophage Polarization; HDL, Activating Transcription Factor, and Macrophage Polarization; Apolipoprotein A-I Mimetic Peptide Design
ApoA-I Mimetic Peptides Were Designed to Mimic a Plasma Apolipoprotein The Peptides Were Effective in a Large Number of Animal Models of Disease; The 4F Peptide Was Tested in Human Clinical Trials; Reconciling the Divergent Results from the Clinical Trials; Overcoming the Barrier of the High Cost of Production of Chemically Synthesized ApoA-I Mimetic Peptides; Determining the Mechanism of Action of Oral ApoA-I Mimetic Peptides; Other Peptides; Conclusions; References; Apolipoprotein Mimetic Peptides for Stimulating Cholesterol Efflux; Introduction; Reverse Cholesterol Transport Pathway
Apolipoprotein Mimetic PeptidesESP24218 Peptide; D-4F Peptide; L-4F Peptide; Retroinverso Peptides; 5A Peptide; ATI-5261 Peptide; Summary; References; ApoA-I Mimetic Peptides and Diabetes; Introduction; 4F Background; 4F and Diabetes; Conclusion; References; Apolipoprotein A-I Mimetic Peptides in Mouse Models of Cancer; Introduction; Inflammation and Lipoproteins in Cancer; ApoA-I and Ovarian Cancer; ApoA-I Mimetic Peptides as Cancer Therapeutics; ApoA-I Mimetic Peptides and Colon Cancer; Conclusions; References
Effects of ApoA-I Mimetic Peptide L-4F in LPS-Mediated InflammationIntroduction; LPS and Sepsis; HDL and LPS; ApoA-I and Sepsis; ApoA-I Mimetic Peptides 18A and 4F; ApoA-I Mimetic Peptide L-4F and LPS; ApoA-I Mimetic Peptide L-4F in Polymicrobial Septic Models; Efficacy of L-4F in Different Models of Atherosclerosis and Metabolic Syndrome (Diabetes) Could Be in Part Accounted for by Its Anti-endotoxin Property; References; Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation; Introduction; Genetic Deletion of ApoA-I; 4F Inhibits Airway Inflammation
Potential Mechanisms of Action Other Apolipoprotein Mimetics That Modulate Airway Inflammation; Novel Apolipoprotein Mimetics; References; Regulation of Macrophage Polarity by HDL, Apolipoproteins, and Apolipoprotein Mimetic Peptides; Introduction; Macrophage Polarization; Macrophage Heterogeneity and Atherosclerosis; HDL Composition and Function; Dysfunctional HDL; HDL-Associated S1P and Macrophage Phenotype; ABCA1 and Macrophage Polarization; HDL, Activating Transcription Factor, and Macrophage Polarization; Apolipoprotein A-I Mimetic Peptide Design