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Kinesins and Cancer [electronic resource] / edited by Frank Kozielski, FSB.

Kozielski, FSB, Frank. editor.
2015
RC261-271
Available Online
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Title
Kinesins and Cancer [electronic resource] / edited by Frank Kozielski, FSB.
Author
Kozielski, FSB, Frank. editor.
ISBN
9789401797320
9401797323
9789401797313
9401797315
DOI
https://doi.org/10.1007/978-94-017-9732-0
Published
Dordrecht : Springer Netherlands : Imprint: Springer, 2015.
Language
English
Description
1 online resource (x, 271 pages) : illustrations.
Item Number
10.1007/978-94-017-9732-0 doi
Call Number
RC261-271
Dewey Decimal Classification
614.5999
Summary
This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development. Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future. The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.
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text file PDF
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Print version: 9789401797313
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Preface
The kinesin superfamily
The discovery and development of Eg5 inhibitors for the clinic
Mechanism of action of Eg5 inhibitors
Clinical trials of mitotic kinesin inhibitors
Kif15; a useful target for anti-cancer therapy?.- Down-regulating CENP-E activity: for better or for worse
The human kinesin-14 motor KifC1/HSET is an attractive anti-cancer drug target.-Kinesin-13 Microtubule Depolymerizing Proteins as targets for cancer therapy
Chromokinesins in genome maintenance and cancer
Kif14: a clinically relevant kinesin and potential target for cancer therapy
Kinesin-8 members and their potential as biomarker or therapeutic target
The kinesin-6 members MKLP1, MKLP2 and MPP
Non-motor spindle proteins as cancer chemotherapy targets
Inhibitors of mitotic kinesins for cancer treatment: consequences for neurons
Index.

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