Inflammatory pathways in diabetes [electronic resource] : biomarkers and clinical correlates / Michael Pugia, editor.

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Inflammatory pathways in diabetes [electronic resource] : biomarkers and clinical correlates / Michael Pugia, editor.

9783319219271 electronic book
3319219278 electronic book
9783319219264

Cham : Springer, [2015]

English

1 online resource : illustrations.

10.1007/978-3-319-21927-1 doi

RC660

616.462072

This book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways. Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases. The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance, metabolic syndrome, nephritis and other diabetic inflammatory conditions, and is the first to describe the impact of novel adipokines, protease inhibitors and complement markers. By presenting new methodologies for biomarker discovery, it provides a valuable resource for researchers studying clinical diagnosis, drug development, bio-analytical chemistry, proteomics and biochemistry. It is also useful for those conducting clinical and biological studies for targeted drug development. The methodologies and approaches can be applied to other markers, and the information will be helpful in the preparation of research grant applications.

Includes bibliographical references and index.

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Online resource; title from PDF title page (viewed October 26, 2015).

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Print version: 9783319219264

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