Synthetic and biophysical studies on the tridachiahydropyrone family of natural products [electronic resource] / Kimberley Jade Powell.

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Synthetic and biophysical studies on the tridachiahydropyrone family of natural products [electronic resource] / Kimberley Jade Powell.

9783319220697 (electronic book)
3319220691 (electronic book)
9783319220680
3319220683

Cham : Springer, 2016.

©2016

English

1 online resource.

10.1007/978-3-319-22069-7 doi

QD415.P69

572

This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs ? the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.

Doctoral Thesis accepted by the University of Nottingham, UK.

Includes bibliographical references and index.

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Online resource; title from PDF title page (viewed August 17, 2015).

Springer theses.

Print version: 9783319220680

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