Synthetic and biophysical studies on the tridachiahydropyrone family of natural products [electronic resource] / Kimberley Jade Powell.
2016
QD415.P69
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Title
Synthetic and biophysical studies on the tridachiahydropyrone family of natural products [electronic resource] / Kimberley Jade Powell.
ISBN
9783319220697 (electronic book)
3319220691 (electronic book)
9783319220680
3319220683
3319220691 (electronic book)
9783319220680
3319220683
Published
Cham : Springer, 2016.
Copyright
©2016
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-319-22069-7 doi
Call Number
QD415.P69
Dewey Decimal Classification
572
Summary
This thesis addresses fundamental scientific questions such as: How are complex natural products synthesized in vivo? Can we replicate these conditions in a laboratory environment? What is the biological function of such secondary metabolites? What are the biological origins of chirality? These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs ? the tridachiahydropyrones. The work has achieved: Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.
Dissertation Note
Doctoral Thesis accepted by the University of Nottingham, UK.
Bibliography, etc. Note
Includes bibliographical references and index.
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Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (viewed August 17, 2015).
Series
Springer theses.
Available in Other Form
Print version: 9783319220680
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Table of Contents
Introduction
Synthesis of the Tridachiahydropyrones and their Biomimetic Precursors
Interactions of the Tridachiahydropyrones with Model Membrane Systems: Biophysical Studies
Investigations into the Photoprotective and Antioxidant Properties of the Tridachiahydropyrones
Summary and Conclusions
Experimental
Synthesis of Alkenyl Nitriles by the Palladium-Catalysed Cyanation of Vinyl Halides with Acetone Cyanohydrin.
Synthesis of the Tridachiahydropyrones and their Biomimetic Precursors
Interactions of the Tridachiahydropyrones with Model Membrane Systems: Biophysical Studies
Investigations into the Photoprotective and Antioxidant Properties of the Tridachiahydropyrones
Summary and Conclusions
Experimental
Synthesis of Alkenyl Nitriles by the Palladium-Catalysed Cyanation of Vinyl Halides with Acetone Cyanohydrin.